Roles of SUMO in replication initiation, progression, and termination Journal Article

   

Authors:	Wei, L.; Zhao, X.
Article Title:	Roles of SUMO in replication initiation, progression, and termination
Abstract:	Accurate genome duplication during cell division is essential for life. This process is accomplished by the close collaboration between replication factors and many additional proteins that provide assistant roles. Replication factors establish the replication machineries capable of copying billions of nucleotides, while regulatory proteins help to achieve accuracy and efficiency of replication. Among regulatory proteins, protein modification enzymes can bestow fast and reversible changes to many targets, leading to coordinated effects on replication. Recent studies have begun to elucidate how one type of protein modification, sumoylation, can modify replication proteins and regulate genome duplication through multiple mechanisms. This chapter summarizes these new findings, and how they can integrate with the known regulatory circuitries of replication. As this area of research is still at its infancy, many outstanding questions remain to be explored, and we discuss these issues in light of the new advances. © 2017, Springer Nature Singapore Pte Ltd.
Keywords:	protein phosphorylation; unclassified drug; nonhuman; dna replication; protein function; sister chromatid; enzyme substrate; phosphorylation; protein processing; ubiquitination; sumoylation; cell adhesion; eukaryote; centromere; protein synthesis inhibition; dna topoisomerase; protein synthesis regulation; budding yeast; replisome; minichromosome maintenance protein; origin recognition complex; posttranslational modifications; human; priority journal; replication initiation; replication progression; dna replication initiation; origin recognition complex 2; replication termination
Journal Title:	Advances in Experimental Medicine and Biology
Volume:	1042
ISSN:	0065-2598
Publisher:	Springer
Date Published:	2017-01-01
Start Page:	371
End Page:	393
Language:	English
DOI:	10.1007/978-981-10-6955-0_17
PROVIDER:	scopus
PUBMED:	29357067
PMCID:	PMC6643980
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041091314&doi=10.1007%2f978-981-10-6955-0_17&partnerID=40&md5=431712c30b3d3a280e8fc367106fd035
Notes:	Chapter 17 in "DNA Replication: From Old Principles to New Discoveries" (ISBN: 978-981-10-6954-3) -- Export Date: 1 March 2018 -- Source: Scopus

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