Apparent diffusion coefficient in estrogen receptor-positive and lymph node-negative invasive breast cancers at 3.0T DW-MRI: A potential predictor for an oncotype Dx test recurrence score Journal Article
| Authors: | Thakur, S. B.; Durando, M.; Milans, S.; Cho, G. Y.; Gennaro, L.; Sutton, E. J.; Giri, D.; Morris, E. A. |
| Article Title: | Apparent diffusion coefficient in estrogen receptor-positive and lymph node-negative invasive breast cancers at 3.0T DW-MRI: A potential predictor for an oncotype Dx test recurrence score |
| Abstract: | Purpose: To measure the apparent diffusion coefficient (ADC) values in estrogen receptor-positive (ER+) and axillary lymph node-negative (LN–) invasive breast cancer and investigate the correlation of ADC with Oncotype Dx test recurrence scores (ODxRS). Materials and Methods: This was a Health Insurance Portability and Accountability Act (HIPAA)-compliant single-site retrospective study. Patients underwent preoperative 3.0T MRI scans with additional diffusion-weighted imaging sequential scans (b = 0, 600 and b = 0, 1000 s/mm2) from January 2011 to 2013. The study population included 31 ER+/LN– invasive breast cancers, which underwent ODxRS genomic testing. ADC600 and ADC1000 parametric maps were generated, and ADC values were calculated from a user-drawn region of interest. ODxRS predicts 10-year recurrence risk in individual patients: low (RS <18), intermediate (RS: 18–30), or high (RS >30). All breast lesions, including subgroups of invasive ductal carcinoma (IDC) lesions and mass-only lesions were dichotomized by RS scores, low-risk versus intermediate/high-risk, and statistical analysis was performed using Mann–Whitney's test (statistical significance at P < 0.05) and receiver operating characteristic (ROC) curves. Multivariate analysis was also performed. Results: Invasive breast cancers, when scored as low-risk by ODxRS, had significantly higher ADC values compared with intermediate/high-risk lesions for both ADC600 (P = 0.007) and ADC1000 (P = 0.008) mean values. This was true both when analyzing only mass-lesions (P = 0.03 and 0.01) or only IDCs (P = 0.001 and 0.009). Conclusion: Preliminary findings suggest that lesion ADC values correlate with recurrence risk likelihood stratified using ODxRS. Hence, ADC is a potential surrogate biomarker for tumor aggressiveness. Level of Evidence: 3. Technical Efficacy: Stage 5. J. Magn. Reson. Imaging 2018;47:401–409. © 2017 International Society for Magnetic Resonance in Medicine. |
| Keywords: | adult; clinical article; controlled study; human tissue; aged; cancer recurrence; recurrence risk; breast cancer; retrospective study; histology; high risk patient; axillary lymph node; scoring system; estrogen receptor; genetic screening; diffusion weighted imaging; receiver operating characteristic; intermediate risk patient; diagnostic test accuracy study; gadolinium pentetate meglumine; apparent diffusion coefficient; diffusion weighted mri; low risk patient; cancer prognosis; estrogen receptor positive breast cancer; dynamic contrast enhanced mri; human; female; priority journal; article; recurrence scores; lymph node negative breast cancer; oncotype dx test recurrence score |
| Journal Title: | Journal of Magnetic Resonance Imaging |
| Volume: | 47 |
| Issue: | 2 |
| ISSN: | 1053-1807 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2018-02-01 |
| Start Page: | 401 |
| End Page: | 409 |
| Language: | English |
| DOI: | 10.1002/jmri.25796 |
| PROVIDER: | scopus |
| PMCID: | PMC5741548 |
| PUBMED: | 28640531 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 February 2018 -- Source: Scopus |
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