Imaging features of hepatocellular carcinoma compared to intrahepatic cholangiocarcinoma and combined tumor on MRI using liver imaging and data system (LI-RADS) version 2014 Journal Article
| Authors: | Horvat, N.; Nikolovski, I.; Long, N.; Gerst, S.; Zheng, J.; Pak, L. M.; Simpson, A.; Zheng, J.; Capanu, M.; Jarnagin, W. R.; Mannelli, L.; Do, R. K. G. |
| Article Title: | Imaging features of hepatocellular carcinoma compared to intrahepatic cholangiocarcinoma and combined tumor on MRI using liver imaging and data system (LI-RADS) version 2014 |
| Abstract: | Purpose: To evaluate the prevalence of major and ancillary imaging features from liver imaging reporting and data systems (LI-RADS) version 2014 and their interreader agreement when comparing hepatocellular carcinoma (HCC) to intrahepatic cholangiocarcinoma (ICC) and combined tumor (cHCC-CC). Methods: The Institutional Review Board approved this HIPAA-compliant retrospective study and waived the requirement for patients’ informed consent. Patients with resected HCC (n = 51), ICC (n = 40), and cHCC-CC (n = 11) and available pre-operative contrast-enhanced MRI were included from 2000 to 2015. Imaging features and final LI-RADS category were evaluated by four radiologists. Imaging features were compared by Fisher’s exact test and interreader agreements were assessed by κ statistics. Results: None of the features were unique to either HCC or non-HCC. Imaging features that were significantly more common among HCC compared to ICC and cHCC-CC included washout (76%–78% vs. 10%–35%, p < 0.001), capsule (55%–71% vs. 16%–49%, p < 0.05), and intralesional fat (27%–52% vs. 2%–12%, p < 0.002). Features that were more common among ICC and cHCC-CC included peripheral arterial phase hyperenhancement (40%–64% vs. 10%–14%, p < 0.001) and progressive central enhancement (65%–82% vs. 14%–25%, p < 0.001). The interreader agreement was moderate for each of these imaging features (κ = 0.41–0.55). Moderate agreement was also achieved in the assignment of LR-M (κ = 0.53), with an overall sensitivity and specificity for non-HCC malignancy of 86.3% and 78.4%, respectively. Conclusion: HCC and non-HCC show significant differences in the prevalence of imaging features defined by LI-RADS, and are identified by radiologists with moderate interreader agreement. Using LI-RADS, radiologists also achieved moderate interreader agreement in the assignment of the LR-M category. © 2017, Springer Science+Business Media, LLC. |
| Keywords: | adult; controlled study; human tissue; aged; middle aged; major clinical study; histopathology; hepatocellular carcinoma; liver cell carcinoma; liver neoplasms; comparative study; gadolinium; nuclear magnetic resonance imaging; magnetic resonance imaging; sensitivity and specificity; image analysis; tumor volume; prevalence; retrospective study; contrast enhancement; liver tumor; clinical evaluation; intrahepatic cholangiocarcinoma; bile duct carcinoma; cholangiocarcinoma; dynamic contrast-enhanced magnetic resonance imaging; diffusion weighted imaging; fisher exact test; clinical assessment tool; single blind procedure; kappa statistics; artery; picture archiving and communication system; gadoxetic acid; human; male; female; priority journal; article; liver imaging reporting and data system |
| Journal Title: | Abdominal Radiology |
| Volume: | 43 |
| Issue: | 1 |
| ISSN: | 2366-004X |
| Publisher: | Springer |
| Date Published: | 2018-01-01 |
| Start Page: | 169 |
| End Page: | 178 |
| Language: | English |
| DOI: | 10.1007/s00261-017-1261-x |
| PROVIDER: | scopus |
| PUBMED: | 28765978 |
| PMCID: | PMC6598685 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 February 2018 -- Source: Scopus |
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