Dedifferentiated liposarcoma of the gastroesophageal junction Journal Article
| Authors: | Aşkan, G.; Bağcı, P.; Hameed, M.; Baştürk, O. |
| Article Title: | Dedifferentiated liposarcoma of the gastroesophageal junction |
| Abstract: | Liposarcoma is one of the most common sarcomas in adults, but very rarely presents as a primary in the upper gastrointestinal system. Herein, we present a 71-year-old male patient who underwent wedge excision biopsy twice and then fine needle aspiration and total gastrectomy for a recurrent gastroeosophageal junction mass. In microscopic sections, both well-differentiated and dedifferentiated components were seen. Tumor cells were positive for MDM2, CDK4 and negative for CD117, DOG1, CD34, SMA, Desmin, S-100, HMB45, SOX10, AE1/AE3, CAM5.2, CK18. Fluorescence in situ hybridization (FISH) was performed and MDM2 gene (12q15) amplification was detected. According to these findings, a diagnosis of dedifferentiated liposarcoma was supported. We believe this is the first reported case of dedifferentiated liposarcoma of the gastroesophageal junction. © 2018, Federation of Turkish Pathology Societies. All rights reserved. |
| Keywords: | gastrointestinal neoplasms; gastroesophageal junction; dedifferentiated liposarcoma |
| Journal Title: | Turk Patoloji Dergisi |
| Volume: | 34 |
| Issue: | 1 |
| ISSN: | 1018-5615 |
| Publisher: | Federation of Turkish Pathology Societies |
| Date Published: | 2018-01-01 |
| Start Page: | 104 |
| End Page: | 107 |
| Language: | English |
| DOI: | 10.5146/tjpath.2014.01297 |
| PROVIDER: | scopus |
| PUBMED: | 25690861 |
| PMCID: | PMC7437155 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2018 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work