| Abstract: |
Purpose: To determine the 15-year outcome for women with ductal carcinoma in situ (DCIS, intraductal carcinoma) of the breast treated with breast- conserving surgery followed by definitive breast irradiation. Patients and Methods: An analysis was performed of 270 intraductal breast carcinomas in 268 women from 10 institutions in Europe and the United States. In all patients, breast-conserving surgery included complete gross excision of the primary tumor followed by definitive breast irradiation. When performed, pathologic axillary lymph node staging was node-negative (n = 86). The median follow-up time was 10.3 years (range, 0.9 to 26.8). Results: The 15-year actuarial overall survival rate was 87%, and the 15-year actuarial cause- specific survival rate was 96%. The 15-year actuarial rate of freedom from distant metastases was 96%. There were 45 local recurrences in the treated breast, and the 15-year actuarial rate of local failure was 19%. The median time to local failure was 5.2 years (range, 1.4 to 16.8). A number of clinical and pathologic parameters were evaluated for correlation with local failure, and none were predictive for local failure (all P ≥ .15). Conclusion: The results from the present study demonstrate rates of overall survival, cause-specific survival, and freedom from distant metastases following the treatment of DCIS of the breast using breast-conserving surgery and definitive breast irradiation. These results support the use of breast- conserving surgery and definitive breast irradiation for the treatment of DCIS of the breast. |
