Proton therapy for head and neck cancers Journal Article


Authors: Blanchard, P.; Gunn, G. B.; Lin, A.; Foote, R. L.; Lee, N. Y.; Frank, S. J.
Article Title: Proton therapy for head and neck cancers
Abstract: Because of its sharp lateral penumbra and steep distal fall-off, proton therapy offers dosimetric advantages over photon therapy. In head and neck cancer, proton therapy has been used for decades in the treatment of skull-base tumors. In recent years the use of proton therapy has been extended to numerous other disease sites, including nasopharynx, oropharynx, nasal cavity and paranasal sinuses, periorbital tumors, skin, and salivary gland, or to reirradiation. The aim of this review is to present the physical properties and dosimetric benefit of proton therapy over advanced photon therapy; to summarize the clinical benefit described for each disease site; and to discuss issues of patient selection and cost-effectiveness. © 2017
Keywords: review; intensity modulated radiation therapy; advanced cancer; cancer risk; patient selection; follow up; diagnostic accuracy; prospective study; computer assisted tomography; skin cancer; practice guideline; cost effectiveness analysis; population research; disease severity; head and neck cancer; intensity-modulated radiotherapy; dosimetry; oropharynx cancer; radiation therapy; salivary gland cancer; nasopharynx cancer; radiation dose distribution; paranasal sinus cancer; proton therapy; re-irradiation; nose cavity cancer; orbit cancer; human; priority journal; intensity-modulated proton therapy; intensity modulated proton therapy
Journal Title: Seminars in Radiation Oncology
Volume: 28
Issue: 1
ISSN: 1053-4296
Publisher: Elsevier Inc.  
Date Published: 2018-01-01
Start Page: 53
End Page: 63
Language: English
DOI: 10.1016/j.semradonc.2017.08.004
PROVIDER: scopus
PUBMED: 29173756
DOI/URL:
Notes: Review -- Export Date: 2 January 2018 -- Source: Scopus
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MSK Authors
  1. Nancy Y. Lee
    549 Lee