Epstein-Barr virus lymphoproliferative disease after solid organ transplantation Journal Article


Authors: Prockop, S. E.; Vatsayan, A.
Article Title: Epstein-Barr virus lymphoproliferative disease after solid organ transplantation
Abstract: Epstein-Barr virus (EBV) was the first identified human oncovirus and is also one of the most ubiquitous viral infections known with established infections in more than 90% of individuals by early adulthood. EBV establishes latency by controlling expression of the viral genome making it silent to immune surveillance. In immunocompetent individuals, up to 1% of circulating T cells are directed at maintaining control over EBV replication. In addition to being involved in oncogenesis of lymphoid and epithelial tumors in immune-competent individuals, loss of immune surveillance over EBV predisposes individuals to EBV malignancies. Lymphoid proliferations from EBV-infected B cells arise in up to 20% of recipients of solid organ transplants (SOTs). One question not answered is why, when EBV requires such active immune surveillance, EBV malignancies are not even more prevalent in severely immune-compromised individuals. A better understanding of who develops complications related to EBV and what the immunologic risks are will ultimately make it feasible to perform prophylactic trials in those at highest risk. This review summarizes our current understanding of factors in SOT recipients that predispose them to the development of an EBV malignancy and that predict response to initial therapy. We then review the current landscape of those therapies, focusing on the goal of restoring long-term EBV-directed immunity to patients at risk. © 2017 International Society for Cellular Therapy
Keywords: treatment response; review; polymerase chain reaction; risk factor; high risk patient; b lymphocyte; cancer center; adoptive transfer; lymphoproliferative disease; immunity; virus replication; immunosurveillance; epstein barr virus; organ transplantation; solid organ transplant; immune therapy; human; priority journal; adoptive therapy; ebv lpd
Journal Title: Cytotherapy
Volume: 19
Issue: 11
ISSN: 1465-3249
Publisher: Elsevier Science Ltd.  
Date Published: 2017-11-01
Start Page: 1270
End Page: 1283
Language: English
DOI: 10.1016/j.jcyt.2017.08.010
PROVIDER: scopus
PUBMED: 28965834
DOI/URL:
Notes: Review -- Export Date: 2 January 2018 -- Source: Scopus
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MSK Authors
  1. Susan E Prockop
    161 Prockop