Spatial rectal dose/volume metrics predict patient-reported gastro-intestinal symptoms after radiotherapy for prostate cancer Conference Paper
| Authors: | Casares-Magaz, O.; Muren, L. P.; Moiseenko, V.; Petersen, S. E.; Pettersson, N. J.; Høyer, M.; Deasy, J. O.; Thor, M. |
| Title: | Spatial rectal dose/volume metrics predict patient-reported gastro-intestinal symptoms after radiotherapy for prostate cancer |
| Conference Title: | 15th Acta Oncologica Conference on Biology-Guided Adaptive Radiotherapy (BiGART2017) |
| Abstract: | Background: Gastro-intestinal (GI) toxicity after radiotherapy (RT) for prostate cancer reduces patient’s quality of life. In this study, we explored associations between spatial rectal dose/volume metrics and patient-reported GI symptoms after RT for localized prostate cancer, and compared these with those of dose–surface/volume histogram (DSH/DVH) metrics. Material and methods: Dose distributions and six GI symptoms (defecation urgency/emptying difficulties/fecal leakage, ≥Grade 2, median follow-up: 3.6 y) were extracted for 200 patients treated with image-guided RT in 2005–2007. Three hundred and nine metrics assessed from 2D rectal dose maps or DSHs/DVHs were subject to 50-times iterated five-fold cross-validated univariate and multivariate logistic regression analysis (UVA, MVA). Performance of the most frequently selected MVA models was evaluated by the area under the receiving–operating characteristics curve (AUC). Results: The AUC increased for dose-map compared to DSH/DVH-based models (mean SD: 0.64 ± 0.03 vs. 0.61 ± 0.01), and significant relations were found for six versus four symptoms. Defecation urgency and faecal leakage were explained by high doses at the central/upper and central areas, respectively; while emptying difficulties were explained by longitudinal extensions of intermediate doses. Conclusions: Predictability of patient-reported GI toxicity increased using spatial metrics compared to DSH/DVH metrics. Novel associations were particularly identified for emptying difficulties using both approaches in which intermediate doses were emphasized. © 2017 Acta Oncologica Foundation. |
| Keywords: | controlled study; major clinical study; cancer radiotherapy; radiation dose; follow up; gastrointestinal symptom; prostate cancer; correlation analysis; correlation coefficient; statistical analysis; clinical evaluation; multivariate logistic regression analysis; flatulence; univariate analysis; radiation dose distribution; histogram; rectum; feces incontinence; patient-reported outcome; defecation disorder; human; male; priority journal; article; defecation urgency; dose surface histogram; dose surface volume |
| Journal Title | Acta Oncologica |
| Volume: | 56 |
| Issue: | 11 |
| Conference Dates: | 2017 Jun 13-16 |
| Conference Location: | Aarhus, Denmark |
| ISBN: | 0284-186X |
| Publisher: | Informa Healthcare |
| Date Published: | 2017-11-01 |
| Start Page: | 1507 |
| End Page: | 1513 |
| Language: | English |
| DOI: | 10.1080/0284186x.2017.1370130 |
| PROVIDER: | scopus |
| PUBMED: | 28885095 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 January 2018 -- Source: Scopus |
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