Balancing the benefits and harms of thyroid cancer surveillance in survivors of childhood, adolescent and young adult cancer: Recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium Journal Article


Authors: Clement, S. C.; Kremer, L. C. M.; Verburg, F. A.; Simmons, J. H.; Goldfarb, M.; Peeters, R. P.; Alexander, E. K.; Bardi, E.; Brignardello, E.; Constine, L. S.; Dinauer, C. A.; Drozd, V. M.; Felicetti, F.; Frey, E.; Heinzel, A.; van den Heuvel-Eibrink, M. M.; Huang, S. A.; Links, T. P.; Lorenz, K.; Mulder, R. L.; Neggers, S. J.; Nieveen van Dijkum, E. J. M.; Oeffinger, K. C.; van Rijn, R. R.; Rivkees, S. A.; Ronckers, C. M.; Schneider, A. B.; Skinner, R.; Wasserman, J. D.; Wynn, T.; Hudson, M. M.; Nathan, P. C.; van Santen, H. M.
Article Title: Balancing the benefits and harms of thyroid cancer surveillance in survivors of childhood, adolescent and young adult cancer: Recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium
Abstract: Radiation exposure to the thyroid gland during treatment of childhood, adolescent and young adult cancer (CAYAC) may cause differentiated thyroid cancer (DTC). Surveillance recommendations for DTC vary considerably, causing uncertainty about optimum screening practices. The International Late Effects of Childhood Cancer Guideline Harmonization Group, in collaboration with the PanCareSurFup Consortium, developed consensus recommendations for thyroid cancer surveillance in CAYAC survivors. These recommendations were developed by an international multidisciplinary panel that included 33 experts in relevant medical specialties who used a consistent and transparent process. Recommendations were graded according to the strength of underlying evidence and potential benefit gained by early detection and appropriate management. Of the two available surveillance strategies, thyroid ultrasound and neck palpation, neither was shown to be superior. Consequently, a decision aid was formulated to guide the health care provider in counseling the survivor. The recommendations highlight the need for shared decision making regarding whether to undergo surveillance for DTC and in the choice of surveillance modality. © 2017 Elsevier Ltd
Keywords: cancer survival; leukemia; cancer surgery; histopathology; review; cancer recurrence; cancer risk; cancer adjuvant therapy; cancer radiotherapy; radiation dose; cancer staging; drug megadose; cancer diagnosis; diagnostic accuracy; gold standard; sensitivity and specificity; evidence based medicine; pain; morbidity; prevalence; practice guideline; risk factor; cancer mortality; childhood cancer; radiation exposure; survivors; postoperative complication; false negative result; radioactive iodine; neuroblastoma; diagnostic value; early diagnosis; echography; patient safety; medical specialist; intermethod comparison; consultation; consensus development; cancer epidemiology; age distribution; radiation hazard; (3 iodobenzyl)guanidine i 131; second cancer; thyroid nodule; anthracycline; malignant transformation; false positive result; patient counseling; cost; palpation; surveillance; teamwork; hypoparathyroidism; shared decision making; differentiated thyroid cancer; fine needle aspiration biopsy; human; childhood cancer/malignancy; late/adverse effects; thyroid cancer/neoplasm
Journal Title: Cancer Treatment Reviews
Volume: 63
ISSN: 0305-7372
Publisher: Elsevier Inc.  
Date Published: 2018-02-01
Start Page: 28
End Page: 39
Language: English
DOI: 10.1016/j.ctrv.2017.11.005
PROVIDER: scopus
PUBMED: 29202445
DOI/URL:
Notes: Review -- Export Date: 2 January 2018 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Kevin Oeffinger
    272 Oeffinger