Vms1 relieves a mitochondrial import chokehold Journal Article
| Authors: | Lamech, L.; Haynes, C. M. |
| Article Title: | Vms1 relieves a mitochondrial import chokehold |
| Abstract: | Ribosome stalling results in the production of truncated proteins that can cause proteotoxic stress if not efficiently degraded. A recent paper by Izawa et al. (2017) identifies Vms1 as a key player in the regulation of ribosome quality control specifically on mitochondria-localized ribosomes, ultimately preventing protein aggregate accumulation within mitochondria. Ribosome stalling results in the production of truncated proteins that can cause proteotoxic stress if not efficiently degraded. A recent paper by Izawa et al. (2017) identifies Vms1 as a key player in the regulation of ribosome quality control specifically on mitochondria-localized ribosomes, ultimately preventing protein aggregate accumulation within mitochondria. © 2017 |
| Keywords: | carrier protein; unclassified drug; protein localization; animal; metabolism; animals; protein; saccharomyces cerevisiae; carrier proteins; short survey; oxidative stress; saccharomyces cerevisiae proteins; saccharomyces cerevisiae protein; mitochondrial protein; mitochondria; mitochondrion; ribosomes; amino acid transfer rna ligase; chaperone; mitochondrial proteins; protein aggregation; ribosome; humans; human; priority journal; protein aggregate; vms1 protein; vms1 protein, s cerevisiae |
| Journal Title: | Developmental Cell |
| Volume: | 43 |
| Issue: | 3 |
| ISSN: | 1534-5807 |
| Publisher: | Cell Press |
| Date Published: | 2017-11-06 |
| Start Page: | 259 |
| End Page: | 260 |
| Language: | English |
| DOI: | 10.1016/j.devcel.2017.10.022 |
| PUBMED: | 29112848 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Short Survey -- Export Date: 2 January 2018 -- Source: Scopus |
