Ponatinib-induced ichthyosiform drug eruption: Insights into acquired ichthyosis Journal Article
| Authors: | Xu, H.; Busam, K. J.; Mauro, M. J.; Markova, A. |
| Article Title: | Ponatinib-induced ichthyosiform drug eruption: Insights into acquired ichthyosis |
| Abstract: | Cutaneous adverse events are commonly experienced with use of tyrosine kinase inhibitors in the treatment of leukemia and typically include nonspecific cutaneous eruptions and xerosis. We report the case of a man who experienced an ichthyosiform drug eruption while taking ponatinib, a third-generation tyrosine kinase inhibitor. Disruption of epidermal growth pathways through inhibition of various receptor tyrosine kinases by ponatinib may offer insights into the pathophysiologic mechanisms behind acquired ichthyosis. © 2017, Dermatology Online Journal. All rights reserved. |
| Keywords: | clinical article; human tissue; aged; prednisone; drug tolerability; case report; cancer combination chemotherapy; methotrexate; drug eruption; skin biopsy; vincristine; cancer therapy; acute lymphoblastic leukemia; rash; abdomen; limb; skin examination; cell therapy; lymphocytic infiltration; corticosteroid; retinoid; drug exposure; xerosis; philadelphia 1 chromosome; mercaptopurine; forehead; urea; skin burning sensation; ichthyosis; skin pruritus; trunk; petrolatum; ointment; drug reactions; ponatinib; granular cell; lanolin; human; male; article; acquired ichthyosis; lamellar ichthyosis |
| Journal Title: | Dermatology Online Journal |
| Volume: | 23 |
| Issue: | 10 |
| ISSN: | 1087-2108 |
| Publisher: | University of California eScholarship |
| Date Published: | 2017-01-01 |
| Start Page: | 5 |
| Language: | English |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 January 2018 -- Source: Scopus |
