Role of anthracycline and comprehensive geriatric assessment for elderly patients with diffuse large B-cell lymphoma Journal Article
| Authors: | Lin, R. J.; Behera, M.; Diefenbach, C. S.; Flowers, C. R. |
| Article Title: | Role of anthracycline and comprehensive geriatric assessment for elderly patients with diffuse large B-cell lymphoma |
| Abstract: | Survival outcome for elderly patients with newly diagnosed diffuse large B-cell lymphoma remains suboptimal in the rituximab era. In this systematic review, we summarize available evidence relevant to the inclusion of anthracycline in upfront chemoimmunotherapy for these elderly patients and highlight the need of prospective clinical trials. With limited prospective data, we find that pretreatment comprehensive geriatric assessment accurately predicts survival and treatment-related toxicities, suggesting its potential role in guiding overall treatment decision-making. © 2017 by The American Society of Hematology. |
| Keywords: | cancer chemotherapy; cancer survival; clinical article; treatment outcome; aged; mortality; review; case report; rituximab; prospective study; medical decision making; weight reduction; information retrieval; dyspnea; arthritis; medline; clinical decision making; lymphoma, large b-cell, diffuse; anthracycline; anthracyclines; geriatric patient; geriatric assessment; night sweat; embase; international prognostic index; diffuse large b cell lymphoma; clinical decision-making; humans; prognosis; human; male; priority journal; generalized lymphadenopathy |
| Journal Title: | Blood |
| Volume: | 130 |
| Issue: | 20 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2017-11-16 |
| Start Page: | 2180 |
| End Page: | 2185 |
| Language: | English |
| DOI: | 10.1182/blood-2017-05-736975 |
| PUBMED: | 28814386 |
| PROVIDER: | scopus |
| PMCID: | PMC5691244 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 January 2018 -- Source: Scopus |
