Liquid biopsy for ctDNA to revolutionize the care of patients with early stage lung cancers Journal Article


Authors: Li, B. T.; Stephens, D.; Chaft, J. E.; Rudin, C. M.; Jones, D. R.; Rusch, V. W.; Rimner, A.; Isbell, J. M.
Article Title: Liquid biopsy for ctDNA to revolutionize the care of patients with early stage lung cancers
Abstract: The current standard of adjuvant therapies for patients with early stage non-small-cell lung cancers largely depends on the stage of disease. Liquid biopsy for circulating tumor DNA (ctDNA) has the potential to detect minimal residual disease, depict genomic evolution, guide precision medicine to individual patients and revolutionize the management of early stage lung cancers. In light of the seminal work published by Abbosh and colleagues, we discuss the potential paradigm changing clinical implications of ctDNA, the biological and technological challenges to consider, and the future of ctDNA driven therapeutic studies. © Annals of Translational Medicine.
Keywords: cancer chemotherapy; unclassified drug; overall survival; sequence analysis; single nucleotide polymorphism; cancer adjuvant therapy; cancer radiotherapy; disease free survival; cancer staging; colorectal cancer; ki 67 antigen; cell proliferation; cancer immunotherapy; tumor volume; gene frequency; lung cancer; relapse; histology; patient care; lung adenocarcinoma; dna; minimal residual disease; childhood leukemia; phylogeny; non small cell lung cancer; tumor necrosis; multiplex polymerase chain reaction; next generation sequencing; cancer prognosis; lymph vessel metastasis; human; article; circulating tumor dna; squamous cell lung carcinoma; variant allele frequency; whole exome sequencing; liquid biopsy; circulating tumor dna (ctdna); genetic sequencing; deep sequencing
Journal Title: Annals of Translational Medicine
Volume: 5
Issue: 23
ISSN: 2305-5839
Publisher: AME Publishing Company  
Date Published: 2017-12-01
Start Page: 479
Language: English
DOI: 10.21037/atm.2017.09.02
PROVIDER: scopus
PMCID: PMC5733322
PUBMED: 29285512
DOI/URL:
Notes: Article -- Export Date: 2 January 2018 -- Source: Scopus
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Citation Impact
MSK Authors
  1. Valerie W Rusch
    783 Rusch
  2. Jamie Erin Chaft
    210 Chaft
  3. Andreas Rimner
    424 Rimner
  4. Charles Rudin
    346 Rudin
  5. David Randolph Jones
    303 Jones
  6. Bob Tingkan Li
    182 Li
  7. James Michael Isbell
    86 Isbell