Nucleotide sequences of MHC class I introns 1, 2, and 3 in humans and intron 2 in nonhuman primates Journal Article
| Authors: | Cereb, N.; Kong, Y.; Lee, S.; Maye, P.; Yang, S. Y. |
| Article Title: | Nucleotide sequences of MHC class I introns 1, 2, and 3 in humans and intron 2 in nonhuman primates |
| Abstract: | HLA-class I genes are the most polymorphic genetic system yet known. The polymorphic substitutions are mostly located in exon 2 and 3, encoding α1 and α2 domains, respectively, which are involved in peptide binding and T cell receptor interaction. In this study, we present the sequences of the introns neighboring the polymorphic exons in humans with few examples from nonhuman primates. In general, intron sequences are found to be less polymorphic than the adjacent exons, displaying numerous locus-specific and group-specific sites. These sequences will provide important information for developing DNA based typing strategies for HLA-class I alleles. |
| Keywords: | clinical article; human cell; exon; nonhuman; animal cell; animals; amino acid substitution; protein binding; intron; introns; t lymphocyte receptor; dna; molecular sequence data; nucleotide sequence; histocompatibility antigens class i; base sequence; dna sequence; hla a antigen; hla b antigen; hla c antigen; hla typing; monkey; primate; dna determination; normal human; gene structure; genetic polymorphism; major histocompatibility antigen class 1; primates; humans; human; priority journal; article; mhc class i gene |
| Journal Title: | Tissue Antigens |
| Volume: | 47 |
| Issue: | 6 |
| ISSN: | 0001-2815 |
| Publisher: | Wiley-Blackwell Publishing, Inc. |
| Date Published: | 1996-06-01 |
| Start Page: | 498 |
| End Page: | 511 |
| Language: | English |
| PUBMED: | 8813739 |
| PROVIDER: | scopus |
| DOI: | 10.1111/j.1399-0039.1996.tb02592.x |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
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