Enhancement of chemotherapeutically-induced apoptosis in vivo by biochemical modulation of poly (ADP-ribose) polymerase Journal Article
| Authors: | Martin, D. S.; Stolfi, R. L.; Nord, L. D.; Colofiore, J. R. |
| Article Title: | Enhancement of chemotherapeutically-induced apoptosis in vivo by biochemical modulation of poly (ADP-ribose) polymerase |
| Abstract: | An inhibitor of poly (ADP-ribose) polymerase, 1,5-dihydroxyisoquinoline (DHIQ), evaluated in vivo against a murine advanced breast cancer, significantly improved by 20% the PR rate of tumor-regressing chemotherapy. A detailed sequential biochemical cascade is proposed for chemotherapy-induced apoptosis, and the rationale for the utilization of the inhibitor is explained. |
| Keywords: | controlled study; unclassified drug; drug potentiation; nonhuman; chemotherapy; antineoplastic agent; mouse; apoptosis; breast cancer; animal experiment; animal model; melphalan; enzyme inhibitor; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; sparfosic acid; 6 aminonicotinamide; biochemical modulation; female; priority journal; article; methylmercaptopurine ribonucleoside; atp depletion; poly (adp-ribose) polymerase; 1,5 dihydroxyisoquinoline |
| Journal Title: | Oncology Reports |
| Volume: | 3 |
| Issue: | 2 |
| ISSN: | 1021-335X |
| Publisher: | Spandidos Publications |
| Date Published: | 1996-03-01 |
| Start Page: | 317 |
| End Page: | 322 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 21594366 |
| DOI: | 10.3892/or.3.2.317 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
