Enhancement of chemotherapeutically-induced apoptosis in vivo by biochemical modulation of poly (ADP-ribose) polymerase Journal Article


Authors: Martin, D. S.; Stolfi, R. L.; Nord, L. D.; Colofiore, J. R.
Article Title: Enhancement of chemotherapeutically-induced apoptosis in vivo by biochemical modulation of poly (ADP-ribose) polymerase
Abstract: An inhibitor of poly (ADP-ribose) polymerase, 1,5-dihydroxyisoquinoline (DHIQ), evaluated in vivo against a murine advanced breast cancer, significantly improved by 20% the PR rate of tumor-regressing chemotherapy. A detailed sequential biochemical cascade is proposed for chemotherapy-induced apoptosis, and the rationale for the utilization of the inhibitor is explained.
Keywords: controlled study; unclassified drug; drug potentiation; nonhuman; chemotherapy; antineoplastic agent; mouse; apoptosis; breast cancer; animal experiment; animal model; melphalan; enzyme inhibitor; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; sparfosic acid; 6 aminonicotinamide; biochemical modulation; female; priority journal; article; methylmercaptopurine ribonucleoside; atp depletion; poly (adp-ribose) polymerase; 1,5 dihydroxyisoquinoline
Journal Title: Oncology Reports
Volume: 3
Issue: 2
ISSN: 1021-335X
Publisher: Spandidos Publications  
Date Published: 1996-03-01
Start Page: 317
End Page: 322
Language: English
PROVIDER: scopus
PUBMED: 21594366
DOI: 10.3892/or.3.2.317
DOI/URL:
Notes: Article -- Export Date: 22 November 2017 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Daniel S Martin
    30 Martin