Coordinate control of growth and cytokeratin 13 expression by retinoic acid Journal Article
| Authors: | Kim, S. Y.; Berger, D.; Yim, S. O.; Sacks, P. G.; Tainsky, M. A. |
| Article Title: | Coordinate control of growth and cytokeratin 13 expression by retinoic acid |
| Abstract: | Retinoic acid (RA) modulates the growth and differentiation of various normal and malignant cells. These effects are most likely mediated by changes in gene expression. Genes whose expression is modulated by RA may be useful as markers of growth responsiveness to retinoids. Using differential cDNA cloning we identified 10 genes regulated by RA in the head and neck squamous cell carcinoma cell line MDA886Ln. Keratin (K) 13 gene expression was the gene expression most related to the degree of sensitivity of growth to RA, as K13 was not expressed in a series of RA-resistant cell lines. Our data suggest that low K13 expression may be mechanistically related to resistance to RA-induced growth inhibition. |
| Keywords: | controlled study; human cell; squamous cell carcinoma; carcinoma, squamous cell; cell division; gene expression; cell line; tumor cells, cultured; head and neck neoplasms; rna, messenger; growth regulation; epithelium; cytokeratin; keratins; retinoic acid; complementary dna; dna, complementary; tretinoin; cdna cloning; humans; human; priority journal; article; growth control |
| Journal Title: | Molecular Carcinogenesis |
| Volume: | 16 |
| Issue: | 1 |
| ISSN: | 0899-1987 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1996-05-01 |
| Start Page: | 6 |
| End Page: | 11 |
| Language: | English |
| DOI: | 10.1002/(sici)1098-2744(199605)16:1<6::aid-mc2>3.0.co;2-i |
| PUBMED: | 8634095 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
