Adjuvant chemotherapy of childhood posterior fossa ependymoma: Cranio-spinal irradiation with or without adjuvant CCNU, vincristine, and prednisone: A Childrens Cancer Group study Journal Article
| Authors: | Evans, A. E.; Anderson, J. R.; Lefkowitz-Boudreaux, I. B.; Finlay, J. L. |
| Article Title: | Adjuvant chemotherapy of childhood posterior fossa ependymoma: Cranio-spinal irradiation with or without adjuvant CCNU, vincristine, and prednisone: A Childrens Cancer Group study |
| Abstract: | In 1975, members of The Children's Cancer Group (CCG) initiated a trial for patients with infratentorial medulloblastomas and ependymonas. Patients, all of whom received post-operative cranio-spinal irradiation (CSI), were randomized to receive or not receive adjuvant chemotherapy (CT) with lomustine (CCNU), vincristine, and prednisone for 1 year. Thirty-six of the 42 patients with ependymoma entered on study were suitable for analysis; 22 received combined modality therapy and 14 irradiation (RT) alone. The failure-free survival (FFS) for the entire sample at 10 years is 36% and overall survival (OS) 39%, with no difference in outcomes between the two regimens. Survival was better for females (73%) than males (21 %) and for those older than 10 years (51% vs. 31%). There were two toxic deaths in the group receiving CT. We condude from this study with long-term follow-up that the CT used was not effective in improving the outcome in children with ependymoma. © 1996 Wiley-Liss, Inc. |
| Keywords: | adolescent; cancer survival; child; clinical article; controlled study; treatment outcome; child, preschool; cancer surgery; prednisone; clinical trial; cancer adjuvant therapy; cancer radiotherapy; chemotherapy, adjuvant; combined modality therapy; brain radiation; brain neoplasms; follow-up studies; neoplasm staging; controlled clinical trial; randomized controlled trial; antineoplastic combined chemotherapy protocols; vincristine; lomustine; cranial irradiation; multicenter study; spinal cord; ependymoma; intravenous drug administration; oral drug administration; posterior cranial fossa tumor; humans; human; male; female; priority journal; article; ccnu; cranial fossa, posterior; childhood ependymoma |
| Journal Title: | Medical and Pediatric Oncology |
| Volume: | 27 |
| Issue: | 1 |
| ISSN: | 0098-1532 |
| Publisher: | Wiley Liss |
| Date Published: | 1996-07-01 |
| Start Page: | 8 |
| End Page: | 14 |
| Language: | English |
| PUBMED: | 8614396 |
| PROVIDER: | scopus |
| DOI: | 10.1002/(SICI)1096-911X(199607)27:1<8::AID-MPO3>3.0.CO;2-K |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
