Growth and final height after treatment for childhood Hodgkin disease Journal Article
| Authors: | Papadakis, V.; Tan, C.; Heller, G.; Sklar, C. |
| Article Title: | Growth and final height after treatment for childhood Hodgkin disease |
| Abstract: | Purpose: To evaluate in children the impact of contemporary treatment for Hodgkin disease on the pattern of growth and final height. Patients and Methods: We studied 80 patients (54 males) aged <14 years at diagnosis, with newly diagnosed, pathologically confirmed Hodgkin disease, treated at a single institution. Forty-six patients received chemotherapy (CT) + radiotherapy (RT), 23 patients received RT alone, and 11 patients received CT alone. Heights were obtained at diagnosis, at the end of treatment, 1, 2, and 3 years after the end of treatment and at attainment of final height. Heights were converted to age- and sex-adjusted SD scores (SDS). Results: There was a significant change in height SDS at the end of treatment compared to height SDS at diagnosis for all three groups (CT + RT: -0.33, p < 0.001; RT: +0.09, p = 0.027; CT: -0.24, p = 0.012). Over the 3 years following treatment, the rate of change of height SDS was not statistically different between the three treatment groups. Final height SDS was decreased for patients receiving RT + CT (-0.41 SDS, p = 0.02; n = 31). The change in final height SDS for patients receiving RT or CT only was -0.36 (n = 14) and +0.42 (n = 4), respectively. Loss of final height SDS correlated with younger age at diagnosis (p = 0.005). Patients receiving higher RT doses tended to fare worse (p = 0.08). Conclusions: Pediatric patients treated for Hodgkin disease with the combination of RT and CT suffer a small but significant decrease in their final height SDS. Younger patients and those treated with higher RT doses appear to experience the greatest loss of height potential. |
| Keywords: | adolescent; cancer chemotherapy; child; child, preschool; major clinical study; prednisone; clinical feature; doxorubicin; cancer radiotherapy; radiation dose; combined modality therapy; chemotherapy; follow-up studies; neoplasm staging; cohort studies; antineoplastic combined chemotherapy protocols; radiotherapy dosage; radiotherapy; cohort analysis; cyclophosphamide; vincristine; procarbazine; hodgkin disease; statistical analysis; radiation therapy; body height; age of onset; radiation field; intravenous drug administration; oral drug administration; growth; humans; human; male; female; priority journal; article; child growth |
| Journal Title: | Journal of Pediatric Hematology/Oncology |
| Volume: | 18 |
| Issue: | 3 |
| ISSN: | 1077-4114 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1996-08-01 |
| Start Page: | 272 |
| End Page: | 276 |
| Language: | English |
| DOI: | 10.1097/00043426-199608000-00007 |
| PUBMED: | 8689340 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
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