Integration of molecular profiling into the lung cancer clinic Journal Article
| Authors: | Pao, W.; Kris, M. G.; Iafrate, A. J.; Ladanyi, M.; Jänne, P. A.; Wistuba, I. I.; Miake-Lye, R.; Herbst, R. S.; Carbone, D. P.; Johnson, B. E.; Lynch, T. J. |
| Article Title: | Integration of molecular profiling into the lung cancer clinic |
| Abstract: | Individuals from five thoracic oncology centers in the United States recently met to discuss how to integrate molecular profiling into the care of all patients with carcinoma of the lung. Lung cancer is an area of medical oncology in which clinicians are beginning to use specific tumor-associated molecular aberrations to assign and/or prioritize targeted therapies for patients. At this early stage, multiple hurdles remain before molecular profiling becomes a routine part of thoracic oncology practice. Concrete collaborative next steps were discussed that could help lead to standardized methods across institutions. In particular, to develop specific targeted therapies for patients whose tumors harbor rare mutations, it will be important for multiple institutions to work together to identify appropriate candidates, design the appropriate trials, and execute the trials with adequate numbers to achieve the necessary end points. Implementation will facilitate realization of the promise of molecularly tailored therapy, which could lead to more effective treatments with fewer side effects. © 2009 American Association for Cancer Research. |
| Keywords: | cancer surgery; gene mutation; mutation; proto-oncogene proteins; clinical trial; review; erlotinib; clinical trials as topic; united states; cancer patient; cancer radiotherapy; biological marker; gene expression profiling; lung neoplasms; epidermal growth factor receptor; epidermal growth factor receptor 2; genotype; lung cancer; clinical protocol; receptor, epidermal growth factor; mutational analysis; cancer therapy; oncogene; patient care; cancer center; dna; medical education; messenger rna; gefitinib; health care personnel; ras proteins; oncogene k ras; genetic procedures; b raf kinase; 5 (4 bromo 2 chloroanilino) 4 fluoro 1 methyl 1h benzimidazole 6 carbohydroxamic acid 2 hydroxyethyl ester; cost benefit analysis; scatter factor receptor; molecular profiling; turnaround time |
| Journal Title: | Clinical Cancer Research |
| Volume: | 15 |
| Issue: | 17 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2009-09-01 |
| Start Page: | 5317 |
| End Page: | 5322 |
| Language: | English |
| DOI: | 10.1158/1078-0432.ccr-09-0913 |
| PUBMED: | 19706816 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 30 November 2010" - "CODEN: CCREF" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work