Regression of C6 rat brain tumors by cells expressing an antisense insulin-like growth factor I receptor RNA Journal Article
| Authors: | Resnicoff, M.; Tjuvajev, J.; Rotman, H. L.; Abraham, D.; Curtis, M.; Aiken, R.; Baserga, R. |
| Article Title: | Regression of C6 rat brain tumors by cells expressing an antisense insulin-like growth factor I receptor RNA |
| Abstract: | We have previously shown that C6 cells expressing an antisense insulin-like growth factor I receptor (IGF-IR) RNA are no longer tumorigenic in syngeneic rats, protecting them from subsequent subcutaneous tumor challenge and causing regression of established subcutaneous tumors. In the present study, we have investigated the efficacy of this strategy on intracerebrally implanted C6 rat glioblastoma cells. We demonstrate that C6 cells expressing an antisense IGF-IR RNA implanted for 24 h in the subcutaneous tissue of the rats are able to elicit an anti-tumor response in the brain, leading to complete brain tumor regression and long-term survival of the rats. These findings suggest the possibility of therapeutic intervention in human gliomas. © 1996 Rapid Science Publishers. |
| Keywords: | survival; survival analysis; brain tumor; glioma; brain neoplasms; animal; metabolism; animals; diffusion; tumor regression; pathology; tumor cells, cultured; somatomedin c receptor; receptor, igf type 1; biosynthesis; cell culture; rat; rats; complementary rna; rna, antisense; antisense; rat strain; rats, inbred strains; humans; human; male; article; insulin-like growth factor i receptor |
| Journal Title: | Journal of Experimental Therapeutics and Oncology |
| Volume: | 1 |
| Issue: | 6 |
| ISSN: | 1359-4117 |
| Publisher: | Old City Publishing, Inc |
| Date Published: | 1996-11-01 |
| Start Page: | 385 |
| End Page: | 389 |
| Language: | English |
| PUBMED: | 9414429 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
