Regression of C6 rat brain tumors by cells expressing an antisense insulin-like growth factor I receptor RNA Journal Article


Authors: Resnicoff, M.; Tjuvajev, J.; Rotman, H. L.; Abraham, D.; Curtis, M.; Aiken, R.; Baserga, R.
Article Title: Regression of C6 rat brain tumors by cells expressing an antisense insulin-like growth factor I receptor RNA
Abstract: We have previously shown that C6 cells expressing an antisense insulin-like growth factor I receptor (IGF-IR) RNA are no longer tumorigenic in syngeneic rats, protecting them from subsequent subcutaneous tumor challenge and causing regression of established subcutaneous tumors. In the present study, we have investigated the efficacy of this strategy on intracerebrally implanted C6 rat glioblastoma cells. We demonstrate that C6 cells expressing an antisense IGF-IR RNA implanted for 24 h in the subcutaneous tissue of the rats are able to elicit an anti-tumor response in the brain, leading to complete brain tumor regression and long-term survival of the rats. These findings suggest the possibility of therapeutic intervention in human gliomas. © 1996 Rapid Science Publishers.
Keywords: survival; survival analysis; brain tumor; glioma; brain neoplasms; animal; metabolism; animals; diffusion; tumor regression; pathology; tumor cells, cultured; somatomedin c receptor; receptor, igf type 1; biosynthesis; cell culture; rat; rats; complementary rna; rna, antisense; antisense; rat strain; rats, inbred strains; humans; human; male; article; insulin-like growth factor i receptor
Journal Title: Journal of Experimental Therapeutics and Oncology
Volume: 1
Issue: 6
ISSN: 1359-4117
Publisher: Old City Publishing, Inc  
Date Published: 1996-11-01
Start Page: 385
End Page: 389
Language: English
PUBMED: 9414429
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 22 November 2017 -- Source: Scopus
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MSK Authors
  1. Juri Gelovani
    125 Gelovani