The role of surgery in the management of gestational trophoblastic disease Journal Article
| Authors: | Jones, W. B.; Wolchok, J.; Lewis, J. L. Jr |
| Article Title: | The role of surgery in the management of gestational trophoblastic disease |
| Abstract: | Between November 1967 and December 1994, 242 patients with gestational trophoblastic disease (GTD) were treated with chemotherapy by the Gynecology Service of Memorial Hospital. Eighty-seven of the patients (35.9%) underwent at least one major operation during the course of their illness. Twenty-six patients underwent two major operations, and in five patients, three major operations were performed, for a total of 118 procedures. The most frequent procedures were: hysterectomy, 56 (47.4%); hysterotomy, 15 (12.7%); thoracotomy, 13 (11%); and craniotomy, 5 (4.2%). Twenty-nine additional procedures ranging in complexity from oophorectomy to segmental liver resection were also performed. Twenty-nine operations (24.5%) were considered to be beyond the scope of most gynecologic surgeons. The overall complete remission rate for 242 patients was 90.4%. The rate for patients who underwent a major surgical procedure was 79.3% compared to 96.7% for patients whose treatment was with chemotherapy alone. The data demonstrate that the integration of surgery in the management of GTD patients often requires a multidisciplinary approach that in many cases can best be achieved at specialized treatment centers. |
| Keywords: | cancer chemotherapy; treatment outcome; major clinical study; antineoplastic agent; hysterectomy; thoracotomy; ovariectomy; high risk patient; liver metastasis; brain metastasis; remission; surgery; liver resection; major surgery; craniotomy; choriocarcinoma; chorionic gonadotropin; trophoblastic disease; human; female; priority journal; article; hysterotomy |
| Journal Title: | International Journal of Gynecological Cancer |
| Volume: | 6 |
| Issue: | 4 |
| ISSN: | 1048-891X |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1996-07-01 |
| Start Page: | 261 |
| End Page: | 266 |
| Language: | English |
| PROVIDER: | scopus |
| DOI: | 10.1046/j.1525-1438.1996.06040261.x |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
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