Duplication of chromosome segment 12q15-24 is associated with atypical lipomatous tumors: A report of the CHAMP collaborative study group Journal Article

  


Authors: Mandahl, N.; Åkerman, M.; Åman, P.; Dal Cin, P.; De Wever, I.; Fletcher, C. D. M.; Mertens, F.; Mitelman, F.; Rosai, J.; Rydholm, A.; Sciot, R.; Tallini, G.; Van Den Berghe, H.; Van De Ven, W.; Vanni, R.; Willén, H.
Article Title: Duplication of chromosome segment 12q15-24 is associated with atypical lipomatous tumors: A report of the CHAMP collaborative study group
Abstract: Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12q13-15, and atypical lipomatous tumors (ALT) by supernumerary ring chromosomes or giant markers known to contain amplified 12q sequences. In a series of 228 cytogenetically analyzed and histopathologically reexamined ordinary lipomas and ALT, 10 tumors showed unbalanced chromosome-12 aberrations. All 4 tumors with loss of segments from 12q were classified as ordinary lipomas, whereas 5 of the 6 tumors showing gain of 12q material were diagnosed as ALT. One or three extra copies of 12q15-q24 were present in all 5 ALT. We conclude that duplication of 12q sequences may be a sufficient level of amplification for development of the microscopic appearance that characterizes ALT.
Keywords: clinical article; controlled study; human tissue; chromosome aberration; chromosome aberrations; karyotyping; chromosome 12q; multigene family; lipoma; chromosomes, human, pair 12; humans; human; male; female; priority journal; article
Journal Title: International Journal of Cancer
Volume: 67
Issue: 5
ISSN: 0020-7136
Publisher: John Wiley & Sons  
Date Published: 1996-09-04
Start Page: 632
End Page: 635
Language: English
DOI: 10.1002/(sici)1097-0215(19960904)67:5<632::aid-ijc7>3.0.co;2-v
PUBMED: 8782650
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-9544238229&doi=10.1002%2f%28SICI%291097-0215%2819960904%2967%3a5%3c632%3a%3aAID-IJC7%3e3.0.CO%3b2-V&partnerID=40&md5=2b8785917182e9c5260201b3d8227907
Notes: Article -- Export Date: 22 November 2017 -- Source: Scopus
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  1. Juan Rosai
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