Peripheral κ1-opioid receptor-mediated analgesia in mice Journal Article

  


Authors: Kolesnikov, Y.; Jain, S.; Wilson, R.; Pasternak, G. W.
Article Title: Peripheral κ1-opioid receptor-mediated analgesia in mice
Abstract: When injected directly into the tail, U50,488H is a potent analgesic in the tailflick assay (ED50 3.1 μg). The analgesic activity is lost if the radiant heat is focused 1 cm away from the site of injection. The κ1-opioid receptor antagonist nor-binaltorphimine given systemically reverses the local analgesic response of U50,488H, but the antagonist is 100-fold more potent when injected directly into the tail. Intrathecal antisense treatment with a probe targeting the mRNA encoding the κ1-opioid receptor blocks the local analgesic actions of U50,488H in the tail, suggesting that U50,488H is acting on dorsal ganglia neurons.
Keywords: controlled study; drug activity; nonhuman; mouse; animal experiment; animal model; analgesia; tail flick test; spinal ganglion; 3,4 dichloro n methyl n [2 (1 pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate; kappa opiate receptor; norbinaltorphimine; male; priority journal; article; κ-opioid receptor; tail-flick assay; intrathecal drug administration; analgesia, peripheral
Journal Title: European Journal of Pharmacology
Volume: 310
Issue: 2-3
ISSN: 0014-2999
Publisher: Elsevier B.V.  
Date Published: 1996-08-29
Start Page: 141
End Page: 143
Language: English
DOI: 10.1016/0014-2999(96)00520-1
PUBMED: 8884210
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030605969&doi=10.1016%2f0014-2999%2896%2900520-1&partnerID=40&md5=4c7b850b7a8bc35a1a519bd26e430140
Notes: Article -- Export Date: 22 November 2017 -- Source: Scopus
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MSK Authors
  1. Roger S Wilson
    38 Wilson
  2. Yuri Alexei Kolesnikov
    34 Kolesnikov
  3. Gavril W Pasternak
    414 Pasternak
  4. Subhash Jain
    23 Jain
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