Authors: | Kolesnikov, Y.; Jain, S.; Wilson, R.; Pasternak, G. W. |
Article Title: | Peripheral κ1-opioid receptor-mediated analgesia in mice |
Abstract: | When injected directly into the tail, U50,488H is a potent analgesic in the tailflick assay (ED50 3.1 μg). The analgesic activity is lost if the radiant heat is focused 1 cm away from the site of injection. The κ1-opioid receptor antagonist nor-binaltorphimine given systemically reverses the local analgesic response of U50,488H, but the antagonist is 100-fold more potent when injected directly into the tail. Intrathecal antisense treatment with a probe targeting the mRNA encoding the κ1-opioid receptor blocks the local analgesic actions of U50,488H in the tail, suggesting that U50,488H is acting on dorsal ganglia neurons. |
Keywords: | controlled study; drug activity; nonhuman; mouse; animal experiment; animal model; analgesia; tail flick test; spinal ganglion; 3,4 dichloro n methyl n [2 (1 pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate; kappa opiate receptor; norbinaltorphimine; male; priority journal; article; κ-opioid receptor; tail-flick assay; intrathecal drug administration; analgesia, peripheral |
Journal Title: | European Journal of Pharmacology |
Volume: | 310 |
Issue: | 2-3 |
ISSN: | 0014-2999 |
Publisher: | Elsevier B.V. |
Date Published: | 1996-08-29 |
Start Page: | 141 |
End Page: | 143 |
Language: | English |
DOI: | 10.1016/0014-2999(96)00520-1 |
PUBMED: | 8884210 |
PROVIDER: | scopus |
DOI/URL: | |
Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |