Elevated serum type III procollagen N-terminal propeptide predicts pulmonary toxicity in patients with advanced non-small cell lung cancer treated with induction mitomycin, vinblastine, and cisplatin Meeting Abstract
| Authors: | Walker, P. A.; Kaner, R. J.; Hanauske-Abel, H. M.; Pizzo, B.; Stolze, E.; Grant, S.; Miller, V.; Young, C. W.; Venkatraman, E.; Stover, D. E.; Kris, M. |
| Abstract Title: | Elevated serum type III procollagen N-terminal propeptide predicts pulmonary toxicity in patients with advanced non-small cell lung cancer treated with induction mitomycin, vinblastine, and cisplatin |
| Meeting Title: | CHEST 1996 |
| Abstract: | Purpose: To establish the utility of serum Type III procollagen N-terminal propeptide (PIIINP) in predicting pulmonary toxicity (pulm tox) during chemotherapy (chemo) for lung cancer. Methods: A prospective study of serum PIIINP levels during induction Mitomycin (M), vinblastine (V), and cisplatin(P) chemo in patients (pts) with advanced non-small cell lung cancer (NSCLC). Serial serum samples from 16 pts during treatment (tx) were analyzed by radioimmunoassay for PIIINP. Pulm tox was prospectively defined. Results: Pts were divided into 3 groups based on the PIIINP levels. Group I (9 pts) had normal (nl) baseline PIIINP values which increased to abnormal levels during treatment. In 7/9 pts in this group, the rise in PIIINP was observed prior to clinical signs of pulm tox. Group II (6 pts) had elevated baseline PIIINP levels and all except 1 pt had Stage IV disease. 5/6 pts in Group II had further increases in their PIIINP levels during tx; the rise preceded the development of pulm tox in 4/5. Group III (1 pt) had nl PIIINP levels throughout and no evidence of pulm tox. 69% of pts met the criteria for pulm tox. 8 of 8 pts treated with systemic corticosteroids improved. Conclusions: An increase in serum PIIINP is a sensitive predictor for the development of MVP-induced pulm tox. Clinical Implications: Serum PIIINP measurements can identify NSCLC pts at risk for pulm tox with MVP tx. |
| Journal Title: | Chest |
| Volume: | 110 |
| Issue: | 4 Suppl. |
| Meeting Dates: | 1996 Oct 27-31 |
| Meeting Location: | San Francisco, CA |
| ISSN: | 0012-3692 |
| Publisher: | American College of Chest Physicians |
| Date Published: | 1996-10-01 |
| Start Page: | 46S |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 8885851 |
| DOI: | 10.1378/chest.110.4_Supplement.45S |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
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