Abstract: |
Purpose: The incidence of supraventricular tachycardia (SVT) and potential etiologic factors for this complication after extrapleural pneumonectomy (EFF) for malignant pleural mesothelioma (MPM) have not been well studied. Methods: We prospectively studied 25 patients undergoing EPP without prior history of dysrhythmias. Transthoracic-Doppler echocardiograms were performed pre-and post-operatively (days 2-4) in 21/25 patients, and preoperatively (only) in 2/25 patients. Estent of resection (±pericardiectomy), pericarditis documented by 12-lead ECG or Holter monitoring and pathologic stage were recorded in a prospective database. Student t-test and Fisher's exact test were used. Results: SVT occurred in 10/25 (40%) patients [atrial fibrillation (n=9), atrial flutter (n=1)]. One patient had a hypoxic event leading to reversible ventricular tachycardia. SVT No SVT RISK FACTOR (n=10) (n=15) P Value Age (Yr) 64±11 54±9 <0.03 Male 9 (90%) 12 (80%) 0.63 Right EPP 7 (70%) 9 (60%) 0.69 Stage: I or III 3 (30%) 6 (40%) 0.69 Stage: III 7 (70%) 9 (60%) Pericardiectomy 4 (40%) 11 (73%) 0.12 Pericarditis-ECG 5 (50%) 5 (33%) 0.07 Right Heart Enlargement 3 (30%) 3 (20%) 0.38 P Value considered significant if <0.05; Conclusions: (1) This prospective study reveals a 40% incidence of SVT after EPP which is higher than reported previously. (2) SVT did not correlate with gender, side of surgery, pathologic stage, pericardial resection or pericarditis detected by ECG. (3) Older age was the only significant risk factor. The usefulness of prophylactic therapy for SVT in these patients is currently being studied. |