Anti-androgenic effects of combination finasteride plus flutamide in patients with prostatic carcinoma Journal Article
| Authors: | Fleshner, N. E.; Fair, W. R. |
| Article Title: | Anti-androgenic effects of combination finasteride plus flutamide in patients with prostatic carcinoma |
| Abstract: | Objectives: To determine the anti-androgenic effects and safety of the combination of finasteride and flutamide in men with prostate cancer. Patients and methods: Seventeen men with various stages of prostate cancer, all of whom were candidates for androgen deprivation therapy, were treated with finasteride plus flutamide and were followed for a mean of 13.6 months using measurements of serum prostate specific antigen (PSA), and an assessment of regression and side-effects. Results: The initial median PSA level was 19.8 ng/mL: at 3, 6 and 12 months the median PSA had fallen to 1.2, 0.85 and 0.8 ng/mL, respectively. In four patients followed for 2 years, the anti-neoplastic effects were sustained. Patients with initially palpable disease had regression, as assessed by a digital rectal examination. Side- effects included gynaecomastia (five patients), mildly elevated hepatic transaminases (two) and diarrhoea (one). Most (10) men maintained their previous sexual function. Conclusions: Early results suggest that the combination of finasteride and flutamide provides significant anti-androgenic therapy and maintains sexual function in most men. A further investigation with more patients and a longer follow-up is warranted. |
| Keywords: | adult; clinical article; treatment outcome; aged; aged, 80 and over; middle aged; clinical trial; cancer combination chemotherapy; follow-up studies; quality of life; antineoplastic combined chemotherapy protocols; prostate cancer; prostate-specific antigen; prostatic neoplasms; gastrointestinal toxicity; androgen antagonists; finasteride; flutamide; drug therapy; gynecomastia; prostate disease; humans; human; male; priority journal; article |
| Journal Title: | British Journal of Urology |
| Volume: | 78 |
| Issue: | 6 |
| ISSN: | 0007-1331 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1996-12-01 |
| Start Page: | 907 |
| End Page: | 910 |
| Language: | English |
| PUBMED: | 9014718 |
| PROVIDER: | scopus |
| DOI: | 10.1046/j.1464-410X.1996.29918.x |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
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