Age at onset of puberty following high-dose central nervous system radiation therapy Journal Article
| Authors: | Oberfield, S. E.; Soranno, D.; Nirenberg, A.; Heller, G.; Allen, J. C.; David, R.; Levine, L. S.; Sklar, C. A. |
| Article Title: | Age at onset of puberty following high-dose central nervous system radiation therapy |
| Abstract: | Objective: To determine if a relationship exists between age at irradiation, sex of the patient, and age at onset of puberty and pubarche in children treated with high-dose radiation to the central nervous system. Design: Case series. Setting: Tertiary care institutional practices and clinics. Patients: Thirty-six children treated with high dose irradiation (hypothalamic pituitary dose, 30-72 Gy) by conventional (n=29) or hyperfractionated (n=7) schedules. Girls were treated before age 8 years and boys before age 9 years. Twenty-six of the 36 children also received chemotherapy. All tumors were distant from the hypothalamic-pituitary region. Main Outcome Measure: Age at onset of puberty and pubarche. Results: In girls, the median age at onset of puberty was 9.3 years vs 10.9 years for controls (P<.01); pubarche occurred at 9.4 years vs 11.2 years for controls (P< 01). In boys, the median age at onset of puberty-genital 11 was 11.0 years vs 11.5 years for controls (P=.30); pubarche occurred at a median age of 10.5 years vs 12 years for controls (P=.25). A censored-data normal linear regression model was used to account for children (n=6) who had not reached puberty. Age at diagnosis (P<01) and sex (P=.01) were significant predictors of age at onset of puberty. Body mass index SD score (z score) was inversely related to age at onset of puberty (r=-0.77) and was greater at onset of puberty in girls than in boys. Conclusion: In children who have received high-dose cranial radiation therapy, a significant positive correlation exists between age at diagnosis and age at onset of puberty in boys and girls. |
| Keywords: | adolescent; child; clinical article; child, preschool; brain radiation; follow-up studies; linear models; radiotherapy dosage; age factors; growth hormone deficiency; hypothalamus hypophysis system; sexual development; puberty; cranial irradiation; central nervous system neoplasms; body mass; body mass index; infant; probability; sex factors; age of onset; humans; human; male; female; priority journal; article |
| Journal Title: | Archives of Pediatrics and Adolescent Medicine |
| Volume: | 150 |
| Issue: | 6 |
| ISSN: | 1072-4710 |
| Publisher: | American Medical Association |
| Date Published: | 1996-06-01 |
| Start Page: | 589 |
| End Page: | 592 |
| Language: | English |
| PUBMED: | 8646307 |
| PROVIDER: | scopus |
| DOI: | 10.1001/archpedi.1996.02170310023003 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
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