Phase II study of ZD1694 in patients with advanced gastric cancer Journal Article
| Authors: | Meropol, N. J.; Pazdur, R.; Vincent, M.; Willson, J. K. V.; Kelsen, D. P.; Douglass, H. O. Jr |
| Article Title: | Phase II study of ZD1694 in patients with advanced gastric cancer |
| Abstract: | ZD1694 (Tomudex(TM)), a quinazoline folate analogue, is a potent and selective thymidylate synthase inhibitor. A phase II trial was undertaken to determine the efficacy and toxicity of ZD1694 in patients with advanced, measurable gastric adenocarcinoma, ZD1694, 3.0 mg/m2, was administered as a 15 min intravenous infusion every three weeks. Tumor measurements were obtained for response assessment every six weeks. Clinical examinations, adverse event assessments, and clinical laboratory tests were performed every three weeks. Thirty-three patients were enrolled. There were no objective responses to ZD1694. In general, treatment was well-tolerated. Grade 3 and 4 toxicities were infrequent, and included mucositis, nausea and vomiting, leukopenia, thrombocytopenia, and elevations of liver enzymes. Mild to moderate asthenia was common. Toxicities with ZD1694 were reversible and manageable. In conclusion, ZD 1694 has an acceptable toxicity profile but shows no antitumor activity in patients with advanced gastric cancer. |
| Keywords: | adult; clinical article; aged; middle aged; clinical trial; fluorouracil; advanced cancer; drug efficacy; paclitaxel; chemotherapy; cancer staging; follow up; follow-up studies; neoplasm staging; adenocarcinoma; phase 2 clinical trial; antimetabolites, antineoplastic; gastrointestinal symptom; leukopenia; mucosa inflammation; nausea; thrombocytopenia; vomiting; antineoplastic activity; drug effect; pathology; enzyme inhibitor; asthenia; alanine aminotransferase; aspartate aminotransferase; blood; drug antagonism; enzyme inhibitors; multicenter study; chemically induced disorder; remission; remission induction; stomach cancer; antiemetic agent; thymidylate synthase; quinazolines; stomach adenocarcinoma; antineoplastic antimetabolite; infusions, intravenous; stomach neoplasms; quinazoline derivative; intravenous drug administration; stomach tumor; mucous membrane; gastric cancer; thiophene derivative; thiophenes; mucosa; raltitrexed; aspartate aminotransferases; alanine transaminase; humans; human; male; female; article; tomudex; zd1694 |
| Journal Title: | American Journal of Clinical Oncology |
| Volume: | 19 |
| Issue: | 6 |
| ISSN: | 0277-3732 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1996-12-01 |
| Start Page: | 628 |
| End Page: | 630 |
| Language: | English |
| DOI: | 10.1097/00000421-199612000-00020 |
| PUBMED: | 8931686 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
