Human trials of stem cell-derived dopamine neurons for Parkinson's disease: Dawn of a new era Journal Article
| Authors: | Barker, R. A.; Parmar, M.; Studer, L.; Takahashi, J. |
| Article Title: | Human trials of stem cell-derived dopamine neurons for Parkinson's disease: Dawn of a new era |
| Abstract: | Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations from our recent fourth GForce-PD meeting. Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations from our recent fourth GForce-PD meeting. © 2017 Elsevier Inc. |
| Keywords: | human cell; patient selection; note; patient assessment; stem cell transplantation; stem cell; immunogenicity; pluripotent stem cell; parkinson disease; immunosuppressive treatment; dopaminergic nerve cell; next generation sequencing; quality of life assessment; human; priority journal |
| Journal Title: | Cell Stem Cell |
| Volume: | 21 |
| Issue: | 5 |
| ISSN: | 1934-5909 |
| Publisher: | Cell Press |
| Date Published: | 2017-11-02 |
| Start Page: | 569 |
| End Page: | 573 |
| Language: | English |
| DOI: | 10.1016/j.stem.2017.09.014 |
| PROVIDER: | scopus |
| PUBMED: | 29100010 |
| DOI/URL: | |
| Notes: | Note -- Export Date: 4 December 2017 -- Source: Scopus |
