Clinically significant mutations in HIV-infected patients with lung adenocarcinoma Journal Article
| Authors: | Thaler, J.; Sigel, C.; Beasley, M. B.; Wisnivesky, J.; Crothers, K.; Bauml, J.; Hysell, K.; Emu, B.; Borsu, L.; Sigel, K. |
| Article Title: | Clinically significant mutations in HIV-infected patients with lung adenocarcinoma |
| Abstract: | BACKGROUND: Lung cancer is a major cause of death in HIV-infected (HIV+) persons. In this study, we compared the prevalence of tumour EGFR and KRAS mutations in a cohort of lung adenocarcinoma patients by HIV status. METHODS: We collected data from 55 HIV+ patients with lung adenocarcinoma matched to 136 uninfected comparators. We compared the prevalence of EGFR and KRAS mutations by HIV status. We then compared survival by HIV status and by cancer mutation status among HIV+ subjects. RESULTS: Presence of KRAS and EGFR genetic alterations did not vary by HIV status (all P>0.1). There was no difference in overall survival by HIV status or by mutation status among HIV+ subjects. CONCLUSIONS: We found no major differences in the prevalence of EGFR or KRAS lung adenocarcinoma mutations by HIV status, suggesting that mutational testing should be conducted similarly regardless of the HIV status. |
| Keywords: | middle aged; survival rate; genetics; mutation; cancer staging; human immunodeficiency virus infection; follow up; follow-up studies; neoplasm staging; adenocarcinoma; cohort studies; lung neoplasms; epidermal growth factor receptor; cohort analysis; receptor, epidermal growth factor; pathology; tumor marker; virology; lung tumor; protein p21; proto-oncogene proteins p21(ras); hiv infections; egfr protein, human; kras protein, human; human immunodeficiency virus 1; hiv-1; humans; prognosis; human; male; female; biomarkers, tumor |
| Journal Title: | British Journal of Cancer |
| Volume: | 117 |
| Issue: | 9 |
| ISSN: | 0007-0920 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2017-10-24 |
| Start Page: | 1392 |
| End Page: | 1395 |
| Language: | English |
| DOI: | 10.1038/bjc.2017.333 |
| PUBMED: | 28934759 |
| PROVIDER: | scopus |
| PMCID: | PMC5672933 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 December 2017 -- Source: Scopus |
