Treatment of gastrointestinal stromal tumours in paediatric and young adult patients with sunitinib: A multicentre case series Journal Article
| Authors: | Rutkowski, P.; Magnan, H.; Chou, A. J.; Benson, C. |
| Article Title: | Treatment of gastrointestinal stromal tumours in paediatric and young adult patients with sunitinib: A multicentre case series |
| Abstract: | Background: Gastrointestinal stromal tumours (GIST) are rarely encountered mesenchymal tumours of the gastrointestinal tract (1.5 people per 100,000/year) that are even more rarely seen in paediatric patients (1-2% of all cases). The standard treatment for advanced adult GIST is imatinib with sunitinib as a second-line option. Although the efficacy and tolerability of sunitinib in adults with GIST has been established, little is known of the profile of sunitinib in paediatric/young adult patients with GIST given the rarity of this disease. Methods: Paediatric/young adult patients aged up to 21 years with diagnosis of GIST who were treated with sunitinib were identified from retrospective records from three centres in Europe and the US. Most patients commenced sunitinib in a 6-week cycle, however, dosing could be reduced, delayed, changed to (or initiated with) a continuous schedule. Objective response (Response Evaluation Criteria In Solid Tumours [RECIST]) and adverse events were recorded. Results: We identified 9 paediatric/young adult patients (aged 11-21 years) with GIST who were treated with sunitinib de novo (n = 1) or following failure of imatinib (n = 8). Progressive disease was previously documented for all patients including 7 patients during imatinib therapy. Baseline patient and tumour profile characteristics showed a distinct profile (notably all were wild-type KIT/PDGFR) compared to that established for adults. Sunitinib treatment was associated with a best response of stable disease for 7 patients, with disease stabilisation lasting from 1 month to >73 months and a median progression free survival time of 15 months. There was some evidence of better disease control for sunitinib when compared to prior imatinib. Most adverse events with sunitinib were manageable and all were consistent with the known profile of the agent. Conclusion: The ability to draw firm conclusions from this case series is limited by the small number of patients and the use of retrospective data which is largely reflective of the rarity of this condition. However, our findings provide initial evidence of clinical benefit and a generally manageable toxicity profile for sunitinib when administered to paediatric/young adult patients with GIST, most of whom had documented progressive disease during prior imatinib treatment. © 2017 The Author(s). |
| Keywords: | adolescent; adult; child; clinical article; young adult; fatigue; sunitinib; diarrhea; drug dose reduction; drug withdrawal; hypertension; gastrointestinal stromal tumor; imatinib; platelet derived growth factor alpha receptor; stem cell factor receptor; edema; progression free survival; multiple cycle treatment; anemia; mucosa inflammation; thrombocytopenia; bone pain; retrospective study; abdominal pain; drug dose escalation; rash; skin discoloration; heartburn; headache; hypothyroidism; gist; drug treatment failure; hand foot syndrome; epistaxis; cholecystitis; case study; hair discoloration; amenorrhea; case series; response evaluation criteria in solid tumors; human; male; female; article; paediatric |
| Journal Title: | BMC Cancer |
| Volume: | 17 |
| ISSN: | 1471-2407 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2017-11-06 |
| Start Page: | 717 |
| Language: | English |
| DOI: | 10.1186/s12885-017-3727-1 |
| PROVIDER: | scopus |
| PMCID: | PMC5674814 |
| PUBMED: | 29110655 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 December 2017 -- Source: Scopus |
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