Measuring depression at the end of life: Is the hamilton depression rating scale a Valid instrument? Journal Article


Authors: Olden, M.; Rosenfeld, B.; Pessin, H.; Breitbart, W.
Article Title: Measuring depression at the end of life: Is the hamilton depression rating scale a Valid instrument?
Abstract: Depression at the end of life is a common mental health issue with serious implications for quality of life and decision making. This study investigated the reliability and validity of one of the most frequently used measures of depression, the Hamilton Depression Rating Scale (HAM-D) in 422 patients with terminal cancer admitted to a palliative care hospital. The HAM-D demonstrated high reliability and concurrent validity with depression diagnosis, based on Structured Clinical Interview for DSM-IV Axis I Disorders, non-patient research version (SCID-I/NP Depression Module). Receiver Operating Characteristic (ROC) analyses generated an area under the curve of.91, indicating high sensitivity and specificity. The HAM-D strongly correlated with several measures of distress (e.g., hopelessness, desire for hastened death, and suicidal ideation). Factor analysis generated 4 factors (anxiety, depressed mood, insomnia, and somatic symptoms), accounting for 42% of the variance. Implications for assessing depression in this population are discussed. © 2009 SAGE Publications.
Keywords: neoplasm; neoplasms; palliative care; reproducibility; reproducibility of results; palliative therapy; terminally ill patient; risk factors; validation study; risk factor; adaptive behavior; psychological aspect; social support; adaptation, psychological; terminally ill; depression; terminal care; roc curve; attitude to death; psychometrics; psychometry; end of life; hamilton (ham-d); terminal illness; psychological model; models, psychological
Journal Title: Assessment
Volume: 16
Issue: 1
ISSN: 1073-1911
Publisher: Sage Publications  
Date Published: 2009-03-01
Start Page: 43
End Page: 54
Language: English
DOI: 10.1177/1073191108320415
PUBMED: 18676960
PROVIDER: scopus
PMCID: PMC3987780
DOI/URL:
Notes: --- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "Source: Scopus"
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  1. William S Breitbart
    505 Breitbart
  2. Hayley Ann Pessin
    88 Pessin