Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma Journal Article


Authors: Thomas, A. A.; Abrey, L. E.; Terziev, R.; Raizer, J.; Martinez, N. L.; Forsyth, P.; Paleologos, N.; Matasar, M.; Sauter, C. S.; Moskowitz, C.; Nimer, S. D.; Deangelis, L. M.; Kaley, T.; Grimm, S.; Louis, D. N.; Cairncross, J. G.; Panageas, K. S.; Briggs, S.; Faivre, G.; Mohile, N. A.; Mehta, J.; Jonsson, P.; Chakravarty, D.; Gao, J.; Schultz, N.; Brennan, C. W.; Huse, J. T.; Omuro, A.
Article Title: Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma
Abstract: Background. Anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA) are chemotherapy-sensitive tumors with prolonged survival after radiochemotherapy. We report a prospective trial using induction temozolomide (TMZ) followed by myeloablative high-dose chemotherapy (HDC) with autologous stem-cell transplant (ASCT) as a potential strategy to defer radiotherapy. Methods. Patients with AO/AOA received 6 cycles of TMZ (200 mg/m2 × 5/28 day). Responding patients were eligible for HDC (thiotepa 250 mg/m2/day © 2017 The Author(s).
Keywords: temozolomide; autologous stem cell transplant; anaplastic oligodendroglioma; 1p/19q codeletion
Journal Title: Neuro-Oncology
Volume: 19
Issue: 10
ISSN: 1522-8517
Publisher: Oxford University Press  
Date Published: 2017-10-01
Start Page: 1380
End Page: 1390
Language: English
DOI: 10.1093/neuonc/nox086
PROVIDER: scopus
PMCID: PMC5596171
PUBMED: 28472509
DOI/URL:
Notes: Article -- Export Date: 2 November 2017 -- Source: Scopus
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MSK Authors
  1. Nimish Arun Mohile
    13 Mohile
  2. Craig Moskowitz
    374 Moskowitz
  3. Cameron Brennan
    155 Brennan
  4. Antonio Marcilio Padula Omuro
    177 Omuro
  5. Thomas Kaley
    89 Kaley
  6. Craig Steven Sauter
    166 Sauter
  7. Stephen D Nimer
    345 Nimer
  8. Lauren E Abrey
    272 Abrey
  9. Matthew J Matasar
    121 Matasar
  10. Katherine S Panageas
    329 Panageas
  11. Jianjiong Gao
    62 Gao
  12. Nikolaus D Schultz
    202 Schultz
  13. Samuel Royden Briggs
    16 Briggs
  14. Alissa A Thomas
    15 Thomas
  15. Geraldine M Faivre
    7 Faivre
  16. Karl Philip Jonsson
    22 Jonsson