Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma Journal Article


Authors: Ducie, J.; Dao, F.; Considine, M.; Olvera, N.; Shaw, P. A.; Kurman, R. J.; Shih, I. M.; Soslow, R. A.; Cope, L.; Levine, D. A.
Article Title: Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma
Abstract: Many high-grade serous carcinomas (HGSCs) of the pelvis are thought to originate in the distal portion of the fallopian tube. Serous tubal intra-epithelial carcinoma (STIC) lesions are the putative precursor to HGSC and identifiable in ~ 50% of advanced stage cases. To better understand the molecular etiology of HGSCs, we report a multi-center integrated genomic analysis of advanced stage tumors with and without STIC lesions and normal tissues. The most significant focal DNA SCNAs were shared between cases with and without STIC lesions. The RNA sequence and the miRNA data did not identify any clear separation between cases with and without STIC lesions. HGSCs had molecular profiles more similar to normal fallopian tube epithelium than ovarian surface epithelium or peritoneum. The data suggest that the molecular features of HGSCs with and without associated STIC lesions are mostly shared, indicating a common biologic origin, likely to be the distal fallopian tube among all cases. © 2017 The Author(s).
Journal Title: Nature Communications
Volume: 8
ISSN: 2041-1723
Publisher: Nature Publishing Group  
Date Published: 2017-10-17
Start Page: 990
Language: English
DOI: 10.1038/s41467-017-01217-9
PROVIDER: scopus
PMCID: PMC5645359
PUBMED: 29042553
DOI/URL:
Notes: Article -- Export Date: 2 November 2017 -- Source: Scopus
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MSK Authors
  1. Douglas A Levine
    357 Levine
  2. Robert Soslow
    655 Soslow
  3. Narciso Olvera
    71 Olvera
  4. Fanny Dao
    56 Dao
  5. Jennifer A Ducie
    15 Ducie