Ets transcription factor GABP controls T cell homeostasis and immunity Journal Article


Authors: Luo, C. T.; Osmanbeyoglu, H. U.; Do, M. H.; Bivona, M. R.; Toure, A.; Kang, D.; Xie, Y.; Leslie, C. S.; Li, M. O.
Article Title: Ets transcription factor GABP controls T cell homeostasis and immunity
Abstract: Peripheral T cells are maintained in the absence of vigorous stimuli, and respond to antigenic stimulation by initiating cell cycle progression and functional differentiation. Here we show that depletion of the Ets family transcription factor GA-binding protein (GABP) in T cells impairs T-cell homeostasis. In addition, GABP is critically required for antigen-stimulated T-cell responses in vitro and in vivo. Transcriptome and genome-wide GABP-binding site analyses identify GABP direct targets encoding proteins involved in cellular redox balance and DNA replication, including the Mcm replicative helicases. These findings show that GABP has a nonredundant role in the control of T-cell homeostasis and immunity. © 2017 The Author(s).
Journal Title: Nature Communications
Volume: 8
ISSN: 2041-1723
Publisher: Nature Publishing Group  
Date Published: 2017-10-20
Start Page: 1062
Language: English
DOI: 10.1038/s41467-017-01020-6
PROVIDER: scopus
PMCID: PMC5648787
PUBMED: 29051483
DOI/URL:
Notes: Article -- Export Date: 2 November 2017 -- Source: Scopus
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MSK Authors
  1. Christina Leslie
    192 Leslie
  2. Ming Li
    111 Li
  3. Michael Richard Bivona
    4 Bivona
  4. Chong Luo
    9 Luo
  5. Ahmed   Toure
    7 Toure
  6. Mytrang   Do
    16 Do
  7. Yuchen Xie
    6 Xie
  8. Davina Kang
    4 Kang