Redox-active nanomaterials for nanomedicine applications Journal Article


Authors: Sims, C. M.; Hanna, S. K.; Heller, D. A.; Horoszko, C. P.; Johnson, M. E.; Montoro Bustos, A. R.; Reipa, V.; Riley, K. R.; Nelson, B. C.
Article Title: Redox-active nanomaterials for nanomedicine applications
Abstract: Nanomedicine utilizes the remarkable properties of nanomaterials for the diagnosis, treatment, and prevention of disease. Many of these nanomaterials have been shown to have robust antioxidative properties, potentially functioning as strong scavengers of reactive oxygen species. Conversely, several nanomaterials have also been shown to promote the generation of reactive oxygen species, which may precipitate the onset of oxidative stress, a state that is thought to contribute to the development of a variety of adverse conditions. As such, the impacts of nanomaterials on biological entities are often associated with and influenced by their specific redox properties. In this review, we overview several classes of nanomaterials that have been or projected to be used across a wide range of biomedical applications, with discussion focusing on their unique redox properties. Nanomaterials examined include iron, cerium, and titanium metal oxide nanoparticles, gold, silver, and selenium nanoparticles, and various nanoscale carbon allotropes such as graphene, carbon nanotubes, fullerenes, and their derivatives/variations. Principal topics of discussion include the chemical mechanisms by which the nanomaterials directly interact with biological entities and the biological cascades that are thus indirectly impacted. Selected case studies highlighting the redox properties of nanomaterials and how they affect biological responses are used to exemplify the biologically-relevant redox mechanisms for each of the described nanomaterials. © 2017 The Royal Society of Chemistry.
Keywords: diagnosis; reactive oxygen species; medical nanotechnology; nanoparticles; metals; carbon; metal nanoparticles; medical applications; biomedical applications; silver; redox reactions; nanostructured materials; chemical mechanism; yarn; titanium oxides; antioxidative property; biological entities; biological response; nanoscale carbon; selenium nanoparticles
Journal Title: Nanoscale
Volume: 9
Issue: 40
ISSN: 2040-3364
Publisher: Royal Society of Chemistry  
Date Published: 2017-10-28
Start Page: 15226
End Page: 15251
Language: English
DOI: 10.1039/c7nr05429g
PROVIDER: scopus
PMCID: PMC5648636
PUBMED: 28991962
DOI/URL:
Notes: Review -- Export Date: 2 November 2017 -- Source: Scopus
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MSK Authors
  1. Daniel Alan Heller
    44 Heller