The effect of ophthalmic artery chemosurgery on immune function in retinoblastoma patients: A single institution retrospective analysis Journal Article
| Authors: | Fischer, C.; Petriccione, M.; Vitolano, S.; Guarini, E.; Davis, M. E.; Dunkel, I. J. |
| Article Title: | The effect of ophthalmic artery chemosurgery on immune function in retinoblastoma patients: A single institution retrospective analysis |
| Abstract: | Background: Ophthalmic artery chemosurgery (OAC) is associated with grade 3 and 4 neutropenia, however the effect on T-cell number and function is unknown. The purpose of this retrospective review was to confirm that patients treated with OAC do not develop immunosuppression warranting Pneumocystis pneumonia prophylaxis. Procedure: IRB approval was obtained for a single center retrospective review of immune function tests in retinoblastoma patients who received OAC. Results: Twenty-three patients received ≥3 cycles of OAC and had immune function testing (absolute CD4 count) performed at a median of 34 days postcompletion of therapy (range, 15 to 63 d). Only 1 patient had a low absolute CD4 count of 189 cells/μL (normal, 359 to 1570 cells/μL) 2 and a half months after IV carboplatin and 28 days after their third dose of OAC. This patient was found to have coexisting hypogammaglobulinemia. Repeat immune function testing normalized through continued OAC treatment. Conclusions: Clinically significant immune suppression appears rare following OAC alone, but patients previously treated with IV chemotherapy may be immunosuppressed and may benefit from pneumocystis pneumonia prophylaxis until the CD4 count recovers. © Copyright 2017 Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | child; clinical article; preschool child; child, preschool; retrospective studies; neutropenia; doxorubicin; topotecan; carboplatin; chemoprophylaxis; immune system; multiple cycle treatment; etoposide; cyclophosphamide; immunoglobulin; melphalan; vincristine; pneumocystis pneumonia; retinoblastoma; retrospective study; immunological tolerance; immunology; immune tolerance; infant; intraarterial drug administration; infusions, intra-arterial; ophthalmic artery; immune function test; cd4 lymphocyte count; immunity; immune deficiency; immunoglobulin deficiency; chemosurgery; eye neoplasms; drug effects; intra-arterial chemotherapy; ophthalmic artery chemosurgery; humans; human; priority journal; article; chemically induced; pneumocystis pneumonia prophylaxis |
| Journal Title: | Journal of Pediatric Hematology/Oncology |
| Volume: | 39 |
| Issue: | 7 |
| ISSN: | 1077-4114 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2017-10-01 |
| Start Page: | 555 |
| End Page: | 559 |
| Language: | English |
| DOI: | 10.1097/mph.0000000000000968 |
| PUBMED: | 28906322 |
| PROVIDER: | scopus |
| PMCID: | PMC5657513 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 November 2017 -- Source: Scopus |
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