Pretargeted imaging and therapy Journal Article
| Authors: | Altai, M.; Membreno, R.; Cook, B.; Tolmachev, V.; Zeglis, B. M. |
| Article Title: | Pretargeted imaging and therapy |
| Abstract: | In vivo pretargeting stands as a promising approach to harnessing the exquisite tumor-targeting properties of antibodies for nuclear imaging and therapy while simultaneously skirting their pharmacokinetic limitations. The core premise of pretargeting lies in administering the targeting vector and radioisotope separately and having the 2 components combine within the body. In this manner, pretargeting strategies decrease the circulation time of the radioactivity, reduce the uptake of the radionuclide in healthy nontarget tissues, and facilitate the use of short-lived radionuclides that would otherwise be incompatible with antibody-based vectors. In this short review, we seek to provide a brief yet informative survey of the 4 preeminent mechanistic approaches to pretargeting, strategies predicated on streptavidin and biotin, bispecific antibodies, complementary oligonucleotides, and bioorthogonal click chemistry. |
| Keywords: | cancer survival; survival rate; unclassified drug; genetics; nonhuman; binding affinity; animal; metabolism; animals; drug structure; diagnostic imaging; structure activity relation; survival time; chemistry; nonhodgkin lymphoma; drug mechanism; isotope labeling; radioactivity; radiopharmaceutical agent; imaging; binding site; antibody specificity; molecular interaction; antigen binding; radioimmunotherapy; indium 111; oligonucleotide; ligand binding; chemical reaction; drug conjugation; streptavidin; antibody affinity; biotin; click chemistry; molecularly targeted therapy; antibody conjugate; immunoconjugates; molecular targeted therapy; yttrium 90; procedures; radioligand; pretargeted radioimmunotherapy; bispecific antibody; pretargeting; humans; human; priority journal; article; tetrazine; peptide nucleic acid; multistep targeting; morpholino oligonucleotide; complementary oligonucleotide; cyclooctene; bioorthogonal click chemistry; inverse electron demand diels alder click reaction; noncovalent interaction; pretargeted imaging |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 58 |
| Issue: | 10 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2017-10-01 |
| Start Page: | 1553 |
| End Page: | 1559 |
| Language: | English |
| DOI: | 10.2967/jnumed.117.189944 |
| PUBMED: | 28687600 |
| PROVIDER: | scopus |
| PMCID: | PMC5632733 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 November 2017 -- Source: Scopus |
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