Predictors of outcome in adenoid cystic carcinoma of salivary glands: A clinicopathologic study with correlation between MYB fusion and protein expression Journal Article

   

Authors:	Xu, B.; Drill, E.; Ho, A.; Ho, A.; Dunn, L.; Prieto-Granada, C. N.; Chan, T.; Ganly, I.; Ghossein, R.; Katabi, N.
Article Title:	Predictors of outcome in adenoid cystic carcinoma of salivary glands: A clinicopathologic study with correlation between MYB fusion and protein expression
Abstract:	Adenoid cystic carcinoma (ACC) is the second most common salivary gland malignancy and it has a high rate of recurrences and a poor long-term prognosis. Our aim was to assess the prognostic factors in ACC and study MYB-NFIB fusion and MYB protein expression in a large retrospective cohort of 135 patients with a median follow-up of 6.3 years. The 5- and 10-year local recurrence-free survival (RFS) rate of 94% and 78%, 5- and 10-year distant metastasis survival rate of 77% and 58%, and 5- and 10-year RFS of 66% and 44%. The following features were identified as adverse prognostic factors of RFS on univariate analysis: large tumor size, solid growth pattern, increased mitoses, positive margin, American Joint Committee on Cancer clinical staging, high-grade transformation, vascular invasion, nuclear atypia, open chromatin, prominent nucleoli, and tumor necrosis. However, on multivariate analysis, only increased mitoses (≥5/10 high-power fields), any solid growth pattern, and advanced American Joint Committee on Cancer TNM staging were independent adverse predictors for RFS. MYB immunoexpression and MYB-NFIB translocation were common findings in ACC, occurring in 72% and 59% of the tested ACCs, respectively. The sensitivity and specificity of MYB immunohistochemistry in detecting MYB-NFIB fusion was relatively low at 78% sensitivity and 50% specificity. The high prevalence of alterations leading to high expression of the MYB transcription factor family suggests that targeted approaches developed to suppress the expression of these oncogenic transcription factors and/or the transcriptional activity of these proteins would be a rational therapeutic approach to investigate in ACC. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
Keywords:	adult; aged; aged, 80 and over; middle aged; retrospective studies; young adult; oncoprotein; metabolism; pathology; retrospective study; histology; biosynthesis; chemistry; protein synthesis; oncogene proteins, fusion; protein biosynthesis; salivary gland tumor; salivary gland neoplasms; adenoid cystic carcinoma; carcinoma, adenoid cystic; nuclear factor i; very elderly; humans; prognosis; human; male; female; nfi transcription factors; myb-nfib fusion; myb immunohistochemistry; nfib protein, human; oncogene proteins v-myb
Journal Title:	American Journal of Surgical Pathology
Volume:	41
Issue:	10
ISSN:	0147-5185
Publisher:	Lippincott Williams & Wilkins
Date Published:	2017-10-01
Start Page:	1422
End Page:	1432
Language:	English
DOI:	10.1097/PAS.0000000000000918
PUBMED:	28719465
PROVIDER:	scopus
PMCID:	PMC5597477
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85024487946&doi=10.1097%2fPAS.0000000000000918&partnerID=40&md5=d490743a32100867e0bc4f750c180df7
Notes:	Article -- Export Date: 1 November 2017 -- Source: Scopus

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