High rate of thiamine deficiency among inpatients with cancer referred for psychiatric consultation: Results of a single site prevalence study Journal Article


Authors: Isenberg-Grzeda, E.; Shen, M. J.; Alici, Y.; Wills, J.; Nelson, C.; Breitbart, W.
Article Title: High rate of thiamine deficiency among inpatients with cancer referred for psychiatric consultation: Results of a single site prevalence study
Abstract: Objective: Thiamine deficiency (TD) is increasingly recognized in medically ill patients. The prevalence of TD among cancer patients is unknown. This study aims to characterize the prevalence of TD among inpatients with cancer. Methods: Retrospective chart review of patients admitted to a large cancer center who were referred for psychiatric consultation and whose serum thiamine concentration was measured. Patients with alcohol use were excluded. Results: Among 217 patients with various cancer types, TD was found in 55.3%. Risk factors included fluorouracil-based chemotherapy, significant weight loss, and undergoing active cancer treatment. Almost all patients were normal weight, overweight, or obese, and few had concomitant vitamin B12 or folate deficiency. A total of 17.5% were receiving multivitamin supplementation. Nearly half (49.8%) did not receive empiric treatment with thiamine and among those who did, treatment delay occurred in the majority of cases (59.6%). Measurement of serum thiamine concentration preceded psychiatric consultation in only 10.6% of cases. Conclusions: Our findings suggest that TD is highly prevalent among inpatients with cancer, even among normal and overweight individuals, in the absence of other vitamin deficiencies, and while receiving multivitamin supplements. Several potential risk factors were identified, including active cancer treatment. Evaluation of TD was most commonly not initiated by oncologists. Failure to treat and treatment delay were common. Given these findings, oncologists must be vigilant about detecting TD among inpatients with cancer. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.
Keywords: nutritional status; neoplasms; prevalence; thiamine; thiamine deficiency
Journal Title: Psycho-Oncology
Volume: 26
Issue: 9
ISSN: 1057-9249
Publisher: John Wiley & Sons  
Date Published: 2017-09-01
Start Page: 1384
End Page: 1389
Language: English
DOI: 10.1002/pon.4155
PROVIDER: scopus
PMCID: PMC5124411
PUBMED: 27228202
DOI/URL:
Notes: Article -- Export Date: 4 October 2017 -- Source: Scopus
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MSK Authors
  1. Yesne Alici
    44 Alici
  2. William S Breitbart
    344 Breitbart
  3. Christian Nelson
    258 Nelson
  4. Jonathan   Wills
    21 Wills