Molecular screening for Lynch syndrome in young patients with colorectal adenomas Journal Article
| Authors: | Mendelsohn, R. B.; Herzog, K.; Shia, J.; Rahaman, N.; Stadler, Z. K.; Shike, M. |
| Article Title: | Molecular screening for Lynch syndrome in young patients with colorectal adenomas |
| Abstract: | Micro-Abstract Lynch syndrome, the most common cause of hereditary colorectal cancer, is caused by mutations in mismatch repair (MMR) proteins. Identification of Lynch syndrome before the cancer diagnosis is critical. We stained 266 polyps of patients aged < 50 years looking for MMR deficiencies and found 1 polyp that was MMR deficient. Routine polyp staining for MMR did not effectively identify LS carriers. © 2017 Elsevier Inc. |
| Keywords: | hereditary nonpolyposis colorectal cancer; colon polyps; mismatch repair proteins; immunohistochemical staining; hereditary colon cancer syndromes |
| Journal Title: | Clinical Colorectal Cancer |
| Volume: | 16 |
| Issue: | 3 |
| ISSN: | 1533-0028 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2017-09-01 |
| Start Page: | 173 |
| End Page: | 177 |
| Language: | English |
| DOI: | 10.1016/j.clcc.2017.01.002 |
| PROVIDER: | scopus |
| PUBMED: | 28242162 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 October 2017 -- Source: Scopus |
