Molecular screening for Lynch syndrome in young patients with colorectal adenomas Journal Article


Authors: Mendelsohn, R. B.; Herzog, K.; Shia, J.; Rahaman, N.; Stadler, Z. K.; Shike, M.
Article Title: Molecular screening for Lynch syndrome in young patients with colorectal adenomas
Abstract: Micro-Abstract Lynch syndrome, the most common cause of hereditary colorectal cancer, is caused by mutations in mismatch repair (MMR) proteins. Identification of Lynch syndrome before the cancer diagnosis is critical. We stained 266 polyps of patients aged < 50 years looking for MMR deficiencies and found 1 polyp that was MMR deficient. Routine polyp staining for MMR did not effectively identify LS carriers. © 2017 Elsevier Inc.
Keywords: hereditary nonpolyposis colorectal cancer; colon polyps; mismatch repair proteins; immunohistochemical staining; hereditary colon cancer syndromes
Journal Title: Clinical Colorectal Cancer
Volume: 16
Issue: 3
ISSN: 1533-0028
Publisher: Elsevier Inc.  
Date Published: 2017-09-01
Start Page: 173
End Page: 177
Language: English
DOI: 10.1016/j.clcc.2017.01.002
PROVIDER: scopus
PUBMED: 28242162
DOI/URL:
Notes: Article -- Export Date: 4 October 2017 -- Source: Scopus
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MSK Authors
  1. Moshe Shike
    106 Shike
  2. Zsofia Kinga Stadler
    152 Stadler
  3. Jinru Shia
    465 Shia