Delineation of tumor habitats based on dynamic contrast enhanced MRI Journal Article


Authors: Chang, Y. C. C.; Ackerstaff, E.; Tschudi, Y.; Jimenez, B.; Foltz, W.; Fisher, C.; Lilge, L.; Cho, H.; Carlin, S.; Gillies, R. J.; Balagurunathan, Y.; Yechieli, R. L.; Subhawong, T.; Turkbey, B.; Pollack, A.; Stoyanova, R.
Article Title: Delineation of tumor habitats based on dynamic contrast enhanced MRI
Abstract: Tumor heterogeneity can be elucidated by mapping subregions of the lesion with differential imaging characteristics, called habitats. Dynamic Contrast Enhanced (DCE-)MRI can depict the tumor microenvironments by identifying areas with variable perfusion and vascular permeability, since individual tumor habitats vary in the rate and magnitude of the contrast uptake and washout. Of particular interest is identifying areas of hypoxia, characterized by inadequate perfusion and hyper-permeable vasculature. An automatic procedure for delineation of tumor habitats from DCE-MRI was developed as a two-part process involving: (1) statistical testing in order to determine the number of the underlying habitats; and (2) an unsupervised pattern recognition technique to recover the temporal contrast patterns and locations of the associated habitats. The technique is examined on simulated data and DCE-MRI, obtained from prostate and brain pre-clinical cancer models, as well as clinical data from sarcoma and prostate cancer patients. The procedure successfully identified habitats previously associated with well-perfused, hypoxic and/or necrotic tumor compartments. Given the association of tumor hypoxia with more aggressive tumor phenotypes, the obtained in vivo information could impact management of cancer patients considerably. © 2017 The Author(s).
Journal Title: Scientific Reports
Volume: 7
ISSN: 2045-2322
Publisher: Nature Publishing Group  
Date Published: 2017-08-29
Start Page: 9746
Language: English
DOI: 10.1038/s41598-017-09932-5
PROVIDER: scopus
PMCID: PMC5575347
PUBMED: 28851989
DOI/URL:
Notes: Article -- Export Date: 2 October 2017 -- Source: Scopus
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  1. Sean Denis Carlin
    83 Carlin