BAK regulates catalase release from peroxisomes Journal Article
| Authors: | Fujiki, Y.; Miyata, N.; Mukai, S.; Okumoto, K.; Cheng, E. H. |
| Article Title: | BAK regulates catalase release from peroxisomes |
| Abstract: | Loss of voltage-dependent anion channel 2 (VDAC2) leads to impaired peroxisome biogenesis in mammalian cells. Knockdown of BAK restores peroxisomal biogenesis in VDAC2-deficient cells, where BAK localization shifts from mitochondria to peroxisomes. Moreover, overexpression of BAK activators in wildtype cells permeabilizes peroxisomes in a BAK-dependent manner. Together, BAK most likely regulates peroxisomal membrane permeability. |
| Keywords: | apoptosis; death; reactive oxygen species; oxidative stress; mitochondria; oligomerization; life; catalase; membrane permeabilization; bak; cho mutant; peroxisome; vdac2 |
| Journal Title: | Molecular & Cellular Oncology |
| Volume: | 4 |
| Issue: | 3 |
| ISSN: | 2372-3556 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2017-01-01 |
| Start Page: | e1306610 |
| Language: | English |
| ACCESSION: | WOS:000406851400004 |
| DOI: | 10.1080/23723556.2017.1306610 |
| PROVIDER: | wos |
| PMCID: | PMC5462519 |
| PUBMED: | 28616584 |
| Notes: | Editorial Material -- Source: Wos |
