Synapse - Genetic analysis of uterine adenosarcomas and phyllodes tumors of the breast

Genetic analysis of uterine adenosarcomas and phyllodes tumors of the breast Journal Article

Authors:	Geyer, F. C.; Burke, K. A.; Piscuoglio, S.; Ng, C. K. Y.; Papanastasiou, A. D.; Marchiò, C.; Selenica, P.; Edelweiss, M.; Murray, M. P.; Brogi, E.; Soslow, R. A.; Rubin, B. P.; Norton, L.; Reis-Filho, J. S.; Weigelt, B.
Article Title:	Genetic analysis of uterine adenosarcomas and phyllodes tumors of the breast
Abstract:	Uterine adenosarcomas and breast phyllodes tumors (PTs) are morphologically similar, being composed of stromal projections in a leaf-like fashion lined by epithelial cells. Here, we investigated whether their histologic similarities would be mirrored at the genetic level. The previously reported repertoires of somatic genetic alterations found in 19 adenosarcomas and 22 PTs (six benign, six borderline, and 10 malignant) were compared. PTs significantly more frequently displayed mutations affecting MED12, the TERT gene promoter and bona fide cancer genes, whereas adenosarcomas harbored a higher rate of MDM2/CDK4 and TERT gene amplifications. Pathway analyses based on the genes affected by somatic genetic alterations in these tumors indicated that Wnt signaling likely plays a role in the biology of adenosarcomas and benign/borderline PTs. In conclusion, despite the differences at the gene level, PTs and adenosarcomas share remarkable morphologic similarities and enrichment for somatic genetic alterations affecting Wnt pathway-related genes. © 2017 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
Keywords:	pathology; gynecology; next-generation sequencing; genotypic–phenotypic correlation; pan-cancer analysis
Journal Title:	Molecular Oncology
Volume:	11
Issue:	8
ISSN:	1878-0261
Publisher:	FEBS Press
Date Published:	2017-08-01
Start Page:	913
End Page:	926
Language:	English
DOI:	10.1002/1878-0261.12049
PROVIDER:	scopus
PMCID:	PMC5537914
PUBMED:	28267263
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026669515&doi=10.1002%2f1878-0261.12049&partnerID=40&md5=ca8d59d6e3a7358a4e88c4d32eca4bcb
Notes:	Article -- Export Date: 5 September 2017 -- Source: Scopus