Genomic evolution of breast cancer metastasis and relapse Journal Article

   


Authors: Yates, L. R.; Knappskog, S.; Wedge, D.; Farmery, J. H. R.; Gonzalez, S.; Martincorena, I.; Alexandrov, L. B.; Van Loo, P.; Haugland, H. K.; Lilleng, P. K.; Gundem, G.; Gerstung, M.; Pappaemmanuil, E.; Gazinska, P.; Bhosle, S. G.; Jones, D.; Raine, K.; Mudie, L.; Latimer, C.; Sawyer, E.; Desmedt, C.; Sotiriou, C.; Stratton, M. R.; Sieuwerts, A. M.; Lynch, A. G.; Martens, J. W.; Richardson, A. L.; Tutt, A.; Lønning, P. E.; Campbell, P. J.
Article Title: Genomic evolution of breast cancer metastasis and relapse
Abstract: Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel of 365 genes on 299 samples from 170 patients with locally relapsed or metastatic breast cancer. Several lines of analysis indicate that clones seeding metastasis or relapse disseminate late from primary tumors, but continue to acquire mutations, mostly accessing the same mutational processes active in the primary tumor. Most distant metastases acquired driver mutations not seen in the primary tumor, drawing from a wider repertoire of cancer genes than early drivers. These include a number of clinically actionable alterations and mutations inactivating SWI-SNF and JAK2-STAT3 pathways. © 2017 The Authors
Keywords: somatic mutation; metastasis; breast cancer; relapse; genomics
Journal Title: Cancer Cell
Volume: 32
Issue: 2
ISSN: 1535-6108
Publisher: Cell Press  
Date Published: 2017-08-14
Start Page: 169
End Page: 184.e7
Language: English
DOI: 10.1016/j.ccell.2017.07.005
PROVIDER: scopus
PMCID: PMC5559645
PUBMED: 28810143
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026812661&doi=10.1016%2fj.ccell.2017.07.005&partnerID=40&md5=71e1d923cdf76fdfd41388bb948a6521
Notes: Article -- Export Date: 5 September 2017 -- Source: Scopus
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  1. Elli Papaemmanuil
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  2. Gunes Gundem
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