The trilogy of GxE: Conceptualization, operationalization, and application Book Section

  


Authors: Grigorenko, E. L.; Bick, J.; Campbell, D. J.; Lewine, G.; Abrams, J.; Nguyen, V.; Chang, J. T.
Editor: Cicchetti, D.
Article/Chapter Title: The trilogy of GxE: Conceptualization, operationalization, and application
Abstract: In this chapter, we intend to introduce this literature and highlight its particularly distinct facets. As an introduction, by definition, is not a comprehensive overview of the field, this chapter is segmented into three parts: the first presents the concept of gene-environment interaction; the second discusses various aspects of the operationalization of the concept; and the third exemplifies issues arising in the actual implementation of the operationalization and application of GxE in empirical research. Thus, the chapter introduces the trilogy of gene-environment interaction (i.e., the presentation and discussion of the phenomenon's conceptualization, operationalization, and implementation). The most intuitively appealing conceptualization of gene-environment interaction (GxE) is the dependence between two factors-the genetic (G) and environmental (E) in their effects on a trait. The presence of GxE is posited when the effect of the genome depends on the immediate environment in which it exists or when, vice versa, the effect of the environment depends on the genome. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
Keywords: genome; gene-environment interaction; conceptualization; operationalization; developmental psychopathology
Book Title: Developmental Psychopathology. 3rd ed
Volume: 2
ISBN: 978-1-118-12179-5
Publisher: John Wiley & Sons  
Publication Place: Hoboken, NJ
Date Published: 2016-01-01
Start Page: 287
End Page: 338
Language: English
ACCESSION: 2016-47345-008
PROVIDER: Ovid Technologies
PROVIDER: psycinfo
DOI/URL:

http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=psyc13&AN=2016-47345-008
Notes: Book chapter: 8 -- Source: PsycINFO