Molecular imaging of PARP Journal Article

   


Authors: Carney, B.; Kossatz, S.; Reiner, T.
Article Title: Molecular imaging of PARP
Abstract: The poly(adenosine diphosphate-ribose)polymerase (PARP) family of enzymes is an important factor in the cellular DNA damage response and has gained much attention for its role in many diseases, particularly cancer. Targeted molecular imaging of PARP using fluorescent or radiolabeled tags has followed on the success of therapeutic inhibitors and gained momentum over the past few years. This review covers PARP imaging from the very first imaging agents up to the current state of the technology, with a focus on the clinical applications made possible by these agents.
Keywords: fluorescence; translation; pet; spect; optical; parp
Journal Title: Journal of Nuclear Medicine
Volume: 58
Issue: 7
ISSN: 0161-5505
Publisher: Society of Nuclear Medicine  
Date Published: 2017-07-01
Start Page: 1025
End Page: 1030
Language: English
DOI: 10.2967/jnumed.117.189936
PROVIDER: scopus
PMCID: PMC5493005
PUBMED: 28473593
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021844309&doi=10.2967%2fjnumed.117.189936&partnerID=40&md5=475660376ddc4ff50dbb9eae43ed6001
Notes: Article -- Export Date: 2 August 2017 -- Source: Scopus
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MSK Authors
  1. Thomas Reiner
    136 Reiner
  2. Susanne Kossatz
    40 Kossatz
  3. Brandon Daniel Carney
    20 Carney
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