Checkpoint inhibition and melanoma: Considerations in treating the older adult Journal Article
| Authors: | Friedman, C. F.; Wolchok, J. D. |
| Article Title: | Checkpoint inhibition and melanoma: Considerations in treating the older adult |
| Abstract: | The incidence of melanoma and associated mortality rate from advanced disease in older adults is increasing over time. Checkpoint inhibitors have demonstrated a survival benefit for the treatment of stage IV or unresectable stage III disease and have become one of the standards of care. Data suggests that adults aged 65 and older benefit from treatment with checkpoint inhibitors without an increased incidence in adverse events. However, clinicians should be aware of the potential side effects of this class of medications and how to manage them in older adults. © 2017 Elsevier Ltd |
| Keywords: | cancer survival; primary tumor; unclassified drug; clinical feature; fatigue; review; advanced cancer; diarrhea; drug safety; monotherapy; side effect; drug targeting; antineoplastic agent; medical decision making; cytotoxic t lymphocyte antigen 4 antibody; ipilimumab; cancer immunotherapy; melanoma; incidence; age; rash; alanine aminotransferase; aspartate aminotransferase; social support; adverse outcome; cytokine production; innate immunity; immunostimulation; adaptive immunity; cytotoxic t lymphocyte antigen 4; immunosuppressive treatment; functional status; immunopathology; programmed death 1 receptor; nivolumab; human; priority journal; checkpoint inhibitor; pembrolizumab; immune-related adverse events; checkpoint inhibitors; programmed death 1 inhibitor |
| Journal Title: | Journal of Geriatric Oncology |
| Volume: | 8 |
| Issue: | 4 |
| ISSN: | 1879-4068 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2017-07-01 |
| Start Page: | 237 |
| End Page: | 241 |
| Language: | English |
| DOI: | 10.1016/j.jgo.2017.04.003 |
| PROVIDER: | scopus |
| PUBMED: | 28506536 |
| PMCID: | PMC5629004 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 August 2017 -- Source: Scopus |
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