Primary CNS lymphoma Journal Article

Authors: Grommes, C.; DeAngelis, L. M.
Article Title: Primary CNS lymphoma
Abstract: Primary CNS lymphoma (PCNSL) is a rare form of extranodal non-Hodgkin lymphoma that is typically confined to the brain, eyes, and cerebrospinal fluid without evidence of systemic spread. The prognosis of patients with PCNSL has improved during the last decades with the introduction of high-dose methotrexate. However, despite recent progress, results after treatment are durable in half of patients, and therapy can be associated with late neurotoxicity. PCNSL is an uncommon tumor, and only four randomized trials and one phase III trial have been completed so far, all in the first-line setting. To our knowledge, no randomized trial has been conducted for recurrent/refractory disease, leaving many questions unanswered about optimal first-line and salvage treatments. This review will give an overview of the presentation, evaluation, and treatment of immunocompetent patients with PCNSL. © 2017 by American Society of Clinical Oncology.
Journal Title: Journal of Clinical Oncology
Volume: 35
Issue: 21
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2017-07-20
Start Page: 2410
End Page: 2418
Language: English
DOI: 10.1200/jco.2017.72.7602
PROVIDER: scopus
PUBMED: 28640701
PMCID: PMC5516483
Notes: Review -- Export Date: 2 August 2017 -- Source: Scopus
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MSK Authors
  1. Christian Grommes
    48 Grommes