Update on antimicrobial resistance in Clostridium difficile: Resistance mechanisms and antimicrobial susceptibility testing Journal Article

   


Authors: Peng, Z.; Jin, D.; Kim, H. B.; Stratton, C. W.; Wu, B.; Tang, Y. W.; Suna, X.
Article Title: Update on antimicrobial resistance in Clostridium difficile: Resistance mechanisms and antimicrobial susceptibility testing
Abstract: Oral antibiotics such as metronidazole, vancomycin and fidaxomicin are therapies of choice for Clostridium difficile infection. Several important mechanisms for C. difficile antibiotic resistance have been described, including the acquisition of antibiotic resistance genes via the transfer of mobile genetic elements, selective pressure in vivo resulting in gene mutations, altered expression of redox-active proteins, iron metabolism, and DNA repair, as well as via biofilm formation. This update summarizes new information published since 2010 on phenotypic and genotypic resistance mechanisms in C. difficile and addresses susceptibility test methods and other strategies to counter antibiotic resistance of C. difficile. Copyright © 2017 American Society for.Microbiology. All Rights Reserved.
Keywords: drug resistance; testing; clostridium difficile; antibiotics; biofilm
Journal Title: Journal of Clinical Microbiology
Volume: 55
Issue: 7
ISSN: 0095-1137
Publisher: American Society for Microbiology  
Date Published: 2017-07-01
Start Page: 1998
End Page: 2008
Language: English
DOI: 10.1128/jcm.02250-16
PROVIDER: scopus
PMCID: PMC5483901
PUBMED: 28404671
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021267374&doi=10.1128%2fJCM.02250-16&partnerID=40&md5=21c53a80e32479c9c38b1e4fa592f6b3
Notes: Review -- Export Date: 2 August 2017 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Yi-Wei Tang
    188 Tang
  2. Dazhi Jin
    5 Jin
Related MSK Work